Autoimmune hepatitis in Japan: trends in a nationwide survey

Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: A nationwide survey of autoimmune hepatitis (AIH) patients was performed in Japan in 2015. The aims of this study were to elucidate the trends and characteristics of AIH in Japan, in addition to identifying differences in AIH between acute hepatitis and chronic hepatitis. Methods: Questionnaires about patients with AIH diagnosed from 2009 to 2013 were sent to 437 hospitals or clinics with hepatology specialists. Results: A total of 1682 patients were enrolled. The mean age at diagnosis was 60.0 years, and 87.1 % of patients were female. Serum immunoglobulin G levels were high, peaking at 1.5–2.0 g/dL. Histological diagnoses of chronic hepatitis, acute hepatitis, and cirrhosis were seen in 79.6, 11.7, and 6.7 % of patients respectively. In addition to elevation of aminotransferase levels, the frequencies of emperipolesis and human leukocyte antigen (HLA)-DR2 positivity were higher in patients with acute hepatitis than in those with chronic hepatitis. Approximately 80 % of patients were treated with corticosteroids, and in 97.7 % of them, their condition improved. Steroid pulse therapy was more frequently given to patients with acute hepatitis than to those with chronic hepatitis. Conclusions: In the present nationwide survey of AIH patients in Japan, patients with acute hepatitis had clinical features different from those of patients with chronic hepatitis.

Original languageEnglish
Pages (from-to)631-640
Number of pages10
JournalJournal of Gastroenterology
Volume52
Issue number5
DOIs
Publication statusPublished - 2017 May 1

Fingerprint

Autoimmune Hepatitis
Japan
Chronic Hepatitis
Hepatitis
Emperipolesis
Surveys and Questionnaires
Gastroenterology
HLA Antigens
Transaminases
Adrenal Cortex Hormones
Fibrosis
Steroids

Keywords

  • Acute hepatitis
  • Autoimmune hepatitis
  • Nationwide survey

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan (2017). Autoimmune hepatitis in Japan: trends in a nationwide survey. Journal of Gastroenterology, 52(5), 631-640. https://doi.org/10.1007/s00535-016-1267-0

Autoimmune hepatitis in Japan : trends in a nationwide survey. / Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan.

In: Journal of Gastroenterology, Vol. 52, No. 5, 01.05.2017, p. 631-640.

Research output: Contribution to journalArticle

Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan 2017, 'Autoimmune hepatitis in Japan: trends in a nationwide survey', Journal of Gastroenterology, vol. 52, no. 5, pp. 631-640. https://doi.org/10.1007/s00535-016-1267-0
Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan. Autoimmune hepatitis in Japan: trends in a nationwide survey. Journal of Gastroenterology. 2017 May 1;52(5):631-640. https://doi.org/10.1007/s00535-016-1267-0
Autoimmune Hepatitis Study Group-Subgroup of the Intractable Hepato-Biliary Disease Study Group in Japan. / Autoimmune hepatitis in Japan : trends in a nationwide survey. In: Journal of Gastroenterology. 2017 ; Vol. 52, No. 5. pp. 631-640.
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AU - Ohira, Hiromasa

AU - Torimura, Takuji

AU - Zeniya, Mikio

AU - Abe, Masanori

AU - Yoshizawa, Kaname

AU - Takaki, Akinobu

AU - Suzuki, Yoshiyuki

AU - Kang, Jong Hon

AU - Nakamoto, Nobuhiro

AU - Fujisawa, Tomoo

AU - Yonemoto, Koji

AU - Tanaka, Atsushi

AU - Takikawa, Hajime

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