Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway

Seiho Nagafuchi, Hitoshi Katsuta, Rimiko Koyanagi-Katsuta, Satoshi Yamasaki, Yasushi Inoue, Kazuya Shimoda, Yukari Ikeda, Mieko Shindo, Eiko Yoshida, Tomohito Matsuo, Yuju Ohno, Kazuhiko Kogawa, Keizo Anzai, Hironori Kurisaki, Jun Kudo, Mine Harada, Nobuyoshi Shimizu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.

Original languageEnglish
Pages (from-to)979-987
Number of pages9
JournalMicrobiology and Immunology
Volume50
Issue number12
Publication statusPublished - 2006

Fingerprint

Regulator Genes
Mitogen-Activated Protein Kinases
Interleukin-2
T-Lymphocytes
p38 Mitogen-Activated Protein Kinases
Autoimmune Polyendocrinopathies
MAP Kinase Kinase 1
MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Protein Kinase Inhibitors
Immune System
Gene Expression
Antigens
Genes

Keywords

  • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
  • Autoimmune regulator (AIRE)
  • Autoimmunity
  • Interleukin-2
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Microbiology

Cite this

Nagafuchi, S., Katsuta, H., Koyanagi-Katsuta, R., Yamasaki, S., Inoue, Y., Shimoda, K., ... Shimizu, N. (2006). Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway. Microbiology and Immunology, 50(12), 979-987.

Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway. / Nagafuchi, Seiho; Katsuta, Hitoshi; Koyanagi-Katsuta, Rimiko; Yamasaki, Satoshi; Inoue, Yasushi; Shimoda, Kazuya; Ikeda, Yukari; Shindo, Mieko; Yoshida, Eiko; Matsuo, Tomohito; Ohno, Yuju; Kogawa, Kazuhiko; Anzai, Keizo; Kurisaki, Hironori; Kudo, Jun; Harada, Mine; Shimizu, Nobuyoshi.

In: Microbiology and Immunology, Vol. 50, No. 12, 2006, p. 979-987.

Research output: Contribution to journalArticle

Nagafuchi, S, Katsuta, H, Koyanagi-Katsuta, R, Yamasaki, S, Inoue, Y, Shimoda, K, Ikeda, Y, Shindo, M, Yoshida, E, Matsuo, T, Ohno, Y, Kogawa, K, Anzai, K, Kurisaki, H, Kudo, J, Harada, M & Shimizu, N 2006, 'Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway', Microbiology and Immunology, vol. 50, no. 12, pp. 979-987.
Nagafuchi, Seiho ; Katsuta, Hitoshi ; Koyanagi-Katsuta, Rimiko ; Yamasaki, Satoshi ; Inoue, Yasushi ; Shimoda, Kazuya ; Ikeda, Yukari ; Shindo, Mieko ; Yoshida, Eiko ; Matsuo, Tomohito ; Ohno, Yuju ; Kogawa, Kazuhiko ; Anzai, Keizo ; Kurisaki, Hironori ; Kudo, Jun ; Harada, Mine ; Shimizu, Nobuyoshi. / Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway. In: Microbiology and Immunology. 2006 ; Vol. 50, No. 12. pp. 979-987.
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