Autoimmune regulator (AIRE) gene is expressed in human activated CD4 + T-cells and regulated by mitogen-activated protein kinase pathway

Seiho Nagafuchi, Hitoshi Katsuta, Rimiko Koyanagi-Katsuta, Satoshi Yamasaki, Yasushi Inoue, Kazuya Shimoda, Yukari Ikeda, Mieko Shindo, Eiko Yoshida, Tomohito Matsuo, Yuju Ohno, Kazuhiko Kogawa, Keizo Anzai, Hironori Kurisaki, Jun Kudoh, Mine Harada, Nobuyoshi Shimizu

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.

Original languageEnglish
Pages (from-to)979-987
Number of pages9
JournalMicrobiology and Immunology
Volume50
Issue number12
DOIs
Publication statusPublished - 2006

Keywords

  • Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
  • Autoimmune regulator (AIRE)
  • Autoimmunity
  • Interleukin-2
  • T lymphocytes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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