Autoimmunity and immunological tolerance in autoimmune bullous diseases

Hayato Takahashi, Hisato Iriki, Miho Mukai, Aki Kamata, Hisashi Nomura, Jun Yamagami, Masayuki Amagai

Research output: Contribution to journalArticle

Abstract

Autoimmune diseases are devastating conditions in which the immune system is directed against the host, leading to life-threatening destruction of organs. Although autoantigens are ill-defined in most autoimmune diseases, this is not the case in the skin. Autoimmune bullous diseases have been extensively studied with detailed characterization of autoantigens, the epitopes that are targeted, and the mechanisms of action that mediate autoimmune tissue destruction. Pemphigus is an autoimmune bullous disease caused by circulating IgG that targets two desmosomal proteins, desmoglein 1 and 3, which are crucial for cell-cell adhesion of keratinocytes. Binding of auto-antibodies to desmogleins impairs keratinocyte adhesion, leading to severe blistering disease. Mouse models that recapitulate the human disease have been instrumental in elucidating the detailed pathophysiology. Taking advantage of the fact that desmogleins are specifically targeted in pemphigus, studying humoral and cellular autoimmunity against these autoantigens provides us with an opportunity to understand not only the effector mechanisms of B and T cells in mediating pathology but also how autoreactive lymphocytes are regulated during development in the thymus and post-development in the periphery. This review introduces pemphigus and its subtypes as prototypic autoimmune diseases from which recent basic and translational developments should provide insight into how autoimmunity develops.

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalInternational immunology
Volume31
Issue number7
DOIs
Publication statusPublished - 2019 Jul 13

Fingerprint

Autoimmunity
Autoimmune Diseases
Pemphigus
Autoantigens
Desmogleins
Keratinocytes
Desmoglein 3
Desmoglein 1
B-Lymphocyte Subsets
Cell Adhesion
Thymus Gland
Epitopes
Immune System
Immunoglobulin G
Lymphocytes
Pathology
T-Lymphocytes
Skin
Antibodies
Proteins

Keywords

  • bronchiolitis obliterans
  • desmoglein
  • interface dermatitis
  • pemphigus
  • tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Autoimmunity and immunological tolerance in autoimmune bullous diseases. / Takahashi, Hayato; Iriki, Hisato; Mukai, Miho; Kamata, Aki; Nomura, Hisashi; Yamagami, Jun; Amagai, Masayuki.

In: International immunology, Vol. 31, No. 7, 13.07.2019, p. 431-437.

Research output: Contribution to journalArticle

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