Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis

Shigeaki Suzuki, Kimiaki Utsugisawa, Kazuo Iwasa, Takashi Satoh, Yuriko Nagane, Hiroaki Yoshikawa, Masataka Kuwana, Norihiro Suzuki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Immune responses to ER stress have been closely related to the pathogenesis of autoimmune diseases. Using an immunoprecipitation assay, 24 (7.1%) of 336 MG serum samples immunoprecipitated a 90-kDa protein from the muscle cellular extracts, but none of the disease or healthy control sera. The 90-kDa protein was affinity-purified and found to match to ER chaperon GRP94 by matrix-assisted laser desorption/ionization-time of flight mass spectroscopy analysis. The frequency of associated autoimmune diseases was much higher in the anti-GRP94-positive than the -negative patients (71% versus 11%, p < 0.001). Autoimmunity to ER chaperone GRP94 is associated with a subset of MG patients who have additional autoimmune diseases.

Original languageEnglish
Pages (from-to)87-92
Number of pages6
JournalJournal of Neuroimmunology
Volume237
Issue number1-2
DOIs
Publication statusPublished - 2011 Aug 15

Keywords

  • Autoantibody
  • Autoimmune diseases
  • ER stress
  • GRP94
  • Immunoprecipitation
  • Myasthenia gravis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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  • Cite this

    Suzuki, S., Utsugisawa, K., Iwasa, K., Satoh, T., Nagane, Y., Yoshikawa, H., Kuwana, M., & Suzuki, N. (2011). Autoimmunity to endoplasmic reticulum chaperone GRP94 in myasthenia gravis. Journal of Neuroimmunology, 237(1-2), 87-92. https://doi.org/10.1016/j.jneuroim.2011.06.011