Autophagic control of listeria through intracellular innate immune recognition in drosophila

Tamaki Yano, Shizuka Mita, Hiroko Ohmori, Yoshiteru Oshima, Yukari Fujimoto, Ryu Ueda, Haruhiko Takada, William E. Goldman, Koichi Fukase, Neal Silverman, Tamotsu Yoshimori, Shoichiro Kurata

Research output: Contribution to journalArticle

252 Citations (Scopus)

Abstract

Autophagy, an evolutionally conserved homeostatic process for catabolizing cytoplasmic components, has been linked to the elimination of intracellular pathogens during mammalian innate immune responses. However, the mechanisms underlying cytoplasmic infection-induced autophagy and the function of autophagy in host survival after infection with intracellular pathogens remain unknown. Here we report that in drosophila, recognition of diaminopimelic acid-type peptidoglycan by the pattern-recognition receptor PGRP-LE was crucial for the induction of autophagy and that autophagy prevented the intracellular growth of Listeria monocytogenes and promoted host survival after this infection. Autophagy induction occurred independently of the Toll and IMD innate signaling pathways. Our findings define a pathway leading from the intracellular pattern-recognition receptors to the induction of autophagy to host defense.

Original languageEnglish
Pages (from-to)908-916
Number of pages9
JournalNature Immunology
Volume9
Issue number8
DOIs
Publication statusPublished - 2008 Aug
Externally publishedYes

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Listeria
Autophagy
Drosophila
Pattern Recognition Receptors
Infection
Diaminopimelic Acid
Peptidoglycan
Listeria monocytogenes
Innate Immunity
Growth

ASJC Scopus subject areas

  • Immunology

Cite this

Autophagic control of listeria through intracellular innate immune recognition in drosophila. / Yano, Tamaki; Mita, Shizuka; Ohmori, Hiroko; Oshima, Yoshiteru; Fujimoto, Yukari; Ueda, Ryu; Takada, Haruhiko; Goldman, William E.; Fukase, Koichi; Silverman, Neal; Yoshimori, Tamotsu; Kurata, Shoichiro.

In: Nature Immunology, Vol. 9, No. 8, 08.2008, p. 908-916.

Research output: Contribution to journalArticle

Yano, T, Mita, S, Ohmori, H, Oshima, Y, Fujimoto, Y, Ueda, R, Takada, H, Goldman, WE, Fukase, K, Silverman, N, Yoshimori, T & Kurata, S 2008, 'Autophagic control of listeria through intracellular innate immune recognition in drosophila', Nature Immunology, vol. 9, no. 8, pp. 908-916. https://doi.org/10.1038/ni.1634
Yano, Tamaki ; Mita, Shizuka ; Ohmori, Hiroko ; Oshima, Yoshiteru ; Fujimoto, Yukari ; Ueda, Ryu ; Takada, Haruhiko ; Goldman, William E. ; Fukase, Koichi ; Silverman, Neal ; Yoshimori, Tamotsu ; Kurata, Shoichiro. / Autophagic control of listeria through intracellular innate immune recognition in drosophila. In: Nature Immunology. 2008 ; Vol. 9, No. 8. pp. 908-916.
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