Abstract
In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
Original language | English |
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Pages (from-to) | 177-186 |
Number of pages | 10 |
Journal | Journal of Neuroimmunology |
Volume | 137 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 2003 Apr |
Keywords
- Acetylcholine receptor α subunit
- Myasthenia gravis
- P3A exon
- T cell
- Thymoma
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology