Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis

Shigeaki Suzuki, Kortaro Tanaka, Hidekata Yasuoka, Yasuo Fukuuchi, Yutaka Kawakami, Masataka Kuwana

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalJournal of Neuroimmunology
Volume137
Issue number1-2
DOIs
Publication statusPublished - 2003 Apr

Fingerprint

Myasthenia Gravis
Cholinergic Receptors
Protein Isoforms
T-Lymphocytes
Tissue Donors
Peptide Fragments
Thymoma
Alternative Splicing
Exons

Keywords

  • Acetylcholine receptor α subunit
  • Myasthenia gravis
  • P3A exon
  • T cell
  • Thymoma

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis. / Suzuki, Shigeaki; Tanaka, Kortaro; Yasuoka, Hidekata; Fukuuchi, Yasuo; Kawakami, Yutaka; Kuwana, Masataka.

In: Journal of Neuroimmunology, Vol. 137, No. 1-2, 04.2003, p. 177-186.

Research output: Contribution to journalArticle

Suzuki, Shigeaki ; Tanaka, Kortaro ; Yasuoka, Hidekata ; Fukuuchi, Yasuo ; Kawakami, Yutaka ; Kuwana, Masataka. / Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis. In: Journal of Neuroimmunology. 2003 ; Vol. 137, No. 1-2. pp. 177-186.
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