Abstract
In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
| Original language | English |
|---|---|
| Pages (from-to) | 177-186 |
| Number of pages | 10 |
| Journal | Journal of Neuroimmunology |
| Volume | 137 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2003 Apr |
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Keywords
- Acetylcholine receptor α subunit
- Myasthenia gravis
- P3A exon
- T cell
- Thymoma
ASJC Scopus subject areas
- Immunology
- Clinical Neurology
- Immunology and Allergy
- Neurology
Cite this
Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis. / Suzuki, Shigeaki; Tanaka, Kortaro; Yasuoka, Hidekata; Fukuuchi, Yasuo; Kawakami, Yutaka; Kuwana, Masataka.
In: Journal of Neuroimmunology, Vol. 137, No. 1-2, 04.2003, p. 177-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis
AU - Suzuki, Shigeaki
AU - Tanaka, Kortaro
AU - Yasuoka, Hidekata
AU - Fukuuchi, Yasuo
AU - Kawakami, Yutaka
AU - Kuwana, Masataka
PY - 2003/4
Y1 - 2003/4
N2 - In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
AB - In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
KW - Acetylcholine receptor α subunit
KW - Myasthenia gravis
KW - P3A exon
KW - T cell
KW - Thymoma
UR - http://www.scopus.com/inward/record.url?scp=0037376649&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037376649&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(03)00078-X
DO - 10.1016/S0165-5728(03)00078-X
M3 - Article
VL - 137
SP - 177
EP - 186
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -