Abstract
In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.
| Original language | English |
|---|---|
| Pages (from-to) | 177-186 |
| Number of pages | 10 |
| Journal | Journal of Neuroimmunology |
| Volume | 137 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2003 Apr |
Keywords
- Acetylcholine receptor α subunit
- Myasthenia gravis
- P3A exon
- T cell
- Thymoma
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
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Cite this
Suzuki, S., Tanaka, K., Yasuoka, H., Fukuuchi, Y., Kawakami, Y., & Kuwana, M. (2003). Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis. Journal of Neuroimmunology, 137(1-2), 177-186. https://doi.org/10.1016/S0165-5728(03)00078-X