Autoreactive T cells to the P3A+ isoform of AChR α subunit in myasthenia gravis

Shigeaki Suzuki, Kortaro Tanaka, Hidekata Yasuoka, Yasuo Fukuuchi, Yutaka Kawakami, Masataka Kuwana

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In vitro T cell proliferative response to an alternative splicing variant of acetylcholine receptor α subunit (AChRα) with the P3A exon-encoded region was examined in peripheral blood samples from 28 myasthenia gravis (MG) patients and 14 healthy donors using recombinant fragments and synthetic peptides. T cells responsive to the P3A region-specific sequences were detected in five MG patients, all of whom were late-onset disease with thymoma, but in none of healthy donors. These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients.

Original languageEnglish
Pages (from-to)177-186
Number of pages10
JournalJournal of Neuroimmunology
Volume137
Issue number1-2
DOIs
Publication statusPublished - 2003 Apr

Keywords

  • Acetylcholine receptor α subunit
  • Myasthenia gravis
  • P3A exon
  • T cell
  • Thymoma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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