Azaelectrocyclization on cell surface: Convenient and general approach to chemical biology research

Akihiro Ogura; Katsunori Tanaka

doi:10.1016/j.tet.2015.02.063

Azaelectrocyclization on cell surface: Convenient and general approach to chemical biology research

Akihiro Ogura, Katsunori Tanaka

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Convenient and general method for live cell surface labeling was established. Azide-containing fluorescences were initially conjugated with the unsaturated ester aldehyde containing the dibenzocyclooctyne (DIBO), by the strain-promoted click reaction. The resulting probes were then treated with the live cells in one-pot process, efficiently labeling the surface lysines by azaelectrocyclization under the mild conditions.

Original language	English
Pages (from-to)	4518-4521
Number of pages	4
Journal	Tetrahedron
Volume	71
Issue number	26-27
DOIs	https://doi.org/10.1016/j.tet.2015.02.063
Publication status	Published - 2015 Jan 13
Externally published	Yes

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Keywords

Azaelectrocyclization
Fluorescence
Labeling
Live cell
Lysine

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

Cite this

Ogura, A., & Tanaka, K. (2015). Azaelectrocyclization on cell surface: Convenient and general approach to chemical biology research. Tetrahedron, 71(26-27), 4518-4521. https://doi.org/10.1016/j.tet.2015.02.063

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10.1016/j.tet.2015.02.063