[B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma].

Yuiko Tsukada; Yutaka Hattori; Hideaki Nakajima; Kenji Yokoyama; Mitsuru Murata; Nobuko Shimizu; Naomi Kondo; Shinichiro Okamoto

[B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma].

Yuiko Tsukada, Yutaka Hattori, Hideaki Nakajima, Kenji Yokoyama, Mitsuru Murata, Nobuko Shimizu, Naomi Kondo, Shinichiro Okamoto

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL). We performed IgH gene rearrangement studies on genomic DNA which revealed the MM, and ALL seemed to be derived from different clones. The development of MM and ALL in the same patient is a very rare event. Further accumulation of the cases to understand the mechanism underlying this event is warranted.

Original language	English
Pages (from-to)	219-223
Number of pages	5
Journal	[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume	53
Issue number	2
Publication status	Published - 2012 Feb

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "[B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma].",

abstract = "A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL). We performed IgH gene rearrangement studies on genomic DNA which revealed the MM, and ALL seemed to be derived from different clones. The development of MM and ALL in the same patient is a very rare event. Further accumulation of the cases to understand the mechanism underlying this event is warranted.",

author = "Yuiko Tsukada and Yutaka Hattori and Hideaki Nakajima and Kenji Yokoyama and Mitsuru Murata and Nobuko Shimizu and Naomi Kondo and Shinichiro Okamoto",

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T1 - [B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma].

AU - Tsukada, Yuiko

AU - Hattori, Yutaka

AU - Nakajima, Hideaki

AU - Yokoyama, Kenji

AU - Murata, Mitsuru

AU - Shimizu, Nobuko

AU - Kondo, Naomi

AU - Okamoto, Shinichiro

PY - 2012/2

Y1 - 2012/2

N2 - A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL). We performed IgH gene rearrangement studies on genomic DNA which revealed the MM, and ALL seemed to be derived from different clones. The development of MM and ALL in the same patient is a very rare event. Further accumulation of the cases to understand the mechanism underlying this event is warranted.

AB - A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL). We performed IgH gene rearrangement studies on genomic DNA which revealed the MM, and ALL seemed to be derived from different clones. The development of MM and ALL in the same patient is a very rare event. Further accumulation of the cases to understand the mechanism underlying this event is warranted.

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[B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma].

Abstract

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