Abstract
A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL). We performed IgH gene rearrangement studies on genomic DNA which revealed the MM, and ALL seemed to be derived from different clones. The development of MM and ALL in the same patient is a very rare event. Further accumulation of the cases to understand the mechanism underlying this event is warranted.
| Original language | English |
|---|---|
| Pages (from-to) | 219-223 |
| Number of pages | 5 |
| Journal | [Rinshō ketsueki] The Japanese journal of clinical hematology |
| Volume | 53 |
| Issue number | 2 |
| Publication status | Published - 2012 Feb |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
[B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma]. / Tsukada, Yuiko; Hattori, Yutaka; Nakajima, Hideaki; Yokoyama, Kenji; Murata, Mitsuru; Shimizu, Nobuko; Kondo, Naomi; Okamoto, Shinichiro.
In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 53, No. 2, 02.2012, p. 219-223.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - [B-cell acute lymphoblastic leukemia developed 5 years after autologous stem cell transplantation for multiple myeloma].
AU - Tsukada, Yuiko
AU - Hattori, Yutaka
AU - Nakajima, Hideaki
AU - Yokoyama, Kenji
AU - Murata, Mitsuru
AU - Shimizu, Nobuko
AU - Kondo, Naomi
AU - Okamoto, Shinichiro
PY - 2012/2
Y1 - 2012/2
N2 - A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL). We performed IgH gene rearrangement studies on genomic DNA which revealed the MM, and ALL seemed to be derived from different clones. The development of MM and ALL in the same patient is a very rare event. Further accumulation of the cases to understand the mechanism underlying this event is warranted.
AB - A 61-year-old female was diagnosed with multiple myeloma (MM) in 2001. After treatment with chemotherapy containing alkylating agents and thalidomide, she underwent autologous stem cell transplantation in 2003, with high-dose melphalan as a conditioning regimen. Thalidomide was also given after the transplant from July 2003 to November 2005 for residual disease and she remained in partial remission. In October 2008, she developed pancytopenia. Bone marrow examination confirmed the diagnosis of acute B lymphoblastic leukemia (B-ALL). We performed IgH gene rearrangement studies on genomic DNA which revealed the MM, and ALL seemed to be derived from different clones. The development of MM and ALL in the same patient is a very rare event. Further accumulation of the cases to understand the mechanism underlying this event is warranted.
UR - http://www.scopus.com/inward/record.url?scp=84865093928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865093928&partnerID=8YFLogxK
M3 - Article
C2 - 22450582
AN - SCOPUS:84865093928
VL - 53
SP - 219
EP - 223
JO - [Rinshō ketsueki] The Japanese journal of clinical hematology
JF - [Rinshō ketsueki] The Japanese journal of clinical hematology
SN - 0485-1439
IS - 2
ER -