B-type natriuretic peptide levels are decreased by reducing dietary salt intake in patients with compensated heart failure with preserved ejection fraction

T. Sadanaga, K. Ando, S. Hirota, H. Mitamura, T. Tsuchihashi, Shun Kosaka, Keiichi Fukuda, S. Ogawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Dietary salt restriction is believed to be a mainstay in the management of patients with heart failure. However, the effect of salt intake on heart failure has not been well evaluated in outpatient medical practice. Aims: The aim of the present study was to assess the hypothesis that B-type natriuretic peptide (BNP) level, as an objective marker of heart failure, is associated with salt intake in patients with heart failure. Methods: One hundred and thirteen consecutive patients with mild compensated heart failure (77 ± 10 years old, 51 female) were included. We estimated dietary salt intake by the concentration of sodium and creatinine in spot urine. We measured BNP at the time of urine sampling and assessed the relationship between the % changes in BNP levels (%ΔBNP) and the changes in the estimated daily salt excretion (ΔNaCl) during the follow-up period. Results: The baseline median BNP level was 150 (interquartile range: 83-263) pg/mL and the estimated daily salt excretion was 162 ± 45mmol/day. There was a positive correlation between %ΔBNP and ΔNaCl (r = 0.61, P < 0.01). Multiple regression analysis revealed that %ΔBNP was associated with ΔNaCl (P < 0.01), but not with changes in systolic blood pressure and bodyweight. Conclusions: Changes in BNP levels were associated with changes in the estimated daily salt excretion in outpatients with compensated heart failure. Salt restriction may be beneficial for the management of patients with heart failure.

Original languageEnglish
Pages (from-to)663-667
Number of pages5
JournalInternal Medicine Journal
Volume43
Issue number6
DOIs
Publication statusPublished - 2013 Jun

Fingerprint

Brain Natriuretic Peptide
Heart Failure
Salts
Outpatients
Urine
Blood Pressure
Creatinine
Sodium
Regression Analysis

Keywords

  • Heart failure
  • Natriuretic peptide
  • Outpatient
  • Salt
  • Spot urine

ASJC Scopus subject areas

  • Internal Medicine

Cite this

B-type natriuretic peptide levels are decreased by reducing dietary salt intake in patients with compensated heart failure with preserved ejection fraction. / Sadanaga, T.; Ando, K.; Hirota, S.; Mitamura, H.; Tsuchihashi, T.; Kosaka, Shun; Fukuda, Keiichi; Ogawa, S.

In: Internal Medicine Journal, Vol. 43, No. 6, 06.2013, p. 663-667.

Research output: Contribution to journalArticle

@article{c778e915d78e491ba1b4eef13b3a9fcf,
title = "B-type natriuretic peptide levels are decreased by reducing dietary salt intake in patients with compensated heart failure with preserved ejection fraction",
abstract = "Background: Dietary salt restriction is believed to be a mainstay in the management of patients with heart failure. However, the effect of salt intake on heart failure has not been well evaluated in outpatient medical practice. Aims: The aim of the present study was to assess the hypothesis that B-type natriuretic peptide (BNP) level, as an objective marker of heart failure, is associated with salt intake in patients with heart failure. Methods: One hundred and thirteen consecutive patients with mild compensated heart failure (77 ± 10 years old, 51 female) were included. We estimated dietary salt intake by the concentration of sodium and creatinine in spot urine. We measured BNP at the time of urine sampling and assessed the relationship between the {\%} changes in BNP levels ({\%}ΔBNP) and the changes in the estimated daily salt excretion (ΔNaCl) during the follow-up period. Results: The baseline median BNP level was 150 (interquartile range: 83-263) pg/mL and the estimated daily salt excretion was 162 ± 45mmol/day. There was a positive correlation between {\%}ΔBNP and ΔNaCl (r = 0.61, P < 0.01). Multiple regression analysis revealed that {\%}ΔBNP was associated with ΔNaCl (P < 0.01), but not with changes in systolic blood pressure and bodyweight. Conclusions: Changes in BNP levels were associated with changes in the estimated daily salt excretion in outpatients with compensated heart failure. Salt restriction may be beneficial for the management of patients with heart failure.",
keywords = "Heart failure, Natriuretic peptide, Outpatient, Salt, Spot urine",
author = "T. Sadanaga and K. Ando and S. Hirota and H. Mitamura and T. Tsuchihashi and Shun Kosaka and Keiichi Fukuda and S. Ogawa",
year = "2013",
month = "6",
doi = "10.1111/imj.12063",
language = "English",
volume = "43",
pages = "663--667",
journal = "Internal Medicine Journal",
issn = "1444-0903",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - B-type natriuretic peptide levels are decreased by reducing dietary salt intake in patients with compensated heart failure with preserved ejection fraction

AU - Sadanaga, T.

AU - Ando, K.

AU - Hirota, S.

AU - Mitamura, H.

AU - Tsuchihashi, T.

AU - Kosaka, Shun

AU - Fukuda, Keiichi

AU - Ogawa, S.

PY - 2013/6

Y1 - 2013/6

N2 - Background: Dietary salt restriction is believed to be a mainstay in the management of patients with heart failure. However, the effect of salt intake on heart failure has not been well evaluated in outpatient medical practice. Aims: The aim of the present study was to assess the hypothesis that B-type natriuretic peptide (BNP) level, as an objective marker of heart failure, is associated with salt intake in patients with heart failure. Methods: One hundred and thirteen consecutive patients with mild compensated heart failure (77 ± 10 years old, 51 female) were included. We estimated dietary salt intake by the concentration of sodium and creatinine in spot urine. We measured BNP at the time of urine sampling and assessed the relationship between the % changes in BNP levels (%ΔBNP) and the changes in the estimated daily salt excretion (ΔNaCl) during the follow-up period. Results: The baseline median BNP level was 150 (interquartile range: 83-263) pg/mL and the estimated daily salt excretion was 162 ± 45mmol/day. There was a positive correlation between %ΔBNP and ΔNaCl (r = 0.61, P < 0.01). Multiple regression analysis revealed that %ΔBNP was associated with ΔNaCl (P < 0.01), but not with changes in systolic blood pressure and bodyweight. Conclusions: Changes in BNP levels were associated with changes in the estimated daily salt excretion in outpatients with compensated heart failure. Salt restriction may be beneficial for the management of patients with heart failure.

AB - Background: Dietary salt restriction is believed to be a mainstay in the management of patients with heart failure. However, the effect of salt intake on heart failure has not been well evaluated in outpatient medical practice. Aims: The aim of the present study was to assess the hypothesis that B-type natriuretic peptide (BNP) level, as an objective marker of heart failure, is associated with salt intake in patients with heart failure. Methods: One hundred and thirteen consecutive patients with mild compensated heart failure (77 ± 10 years old, 51 female) were included. We estimated dietary salt intake by the concentration of sodium and creatinine in spot urine. We measured BNP at the time of urine sampling and assessed the relationship between the % changes in BNP levels (%ΔBNP) and the changes in the estimated daily salt excretion (ΔNaCl) during the follow-up period. Results: The baseline median BNP level was 150 (interquartile range: 83-263) pg/mL and the estimated daily salt excretion was 162 ± 45mmol/day. There was a positive correlation between %ΔBNP and ΔNaCl (r = 0.61, P < 0.01). Multiple regression analysis revealed that %ΔBNP was associated with ΔNaCl (P < 0.01), but not with changes in systolic blood pressure and bodyweight. Conclusions: Changes in BNP levels were associated with changes in the estimated daily salt excretion in outpatients with compensated heart failure. Salt restriction may be beneficial for the management of patients with heart failure.

KW - Heart failure

KW - Natriuretic peptide

KW - Outpatient

KW - Salt

KW - Spot urine

UR - http://www.scopus.com/inward/record.url?scp=84879023933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879023933&partnerID=8YFLogxK

U2 - 10.1111/imj.12063

DO - 10.1111/imj.12063

M3 - Article

C2 - 23279137

AN - SCOPUS:84879023933

VL - 43

SP - 663

EP - 667

JO - Internal Medicine Journal

JF - Internal Medicine Journal

SN - 1444-0903

IS - 6

ER -