Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Mariko Yokogawa, Takahiro Muramatsu, Koh Takeuchi, Masanori Osawa, Ichio Shimada

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein βγ subunits (Gβγ), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of 2H/13C/15N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalBiomolecular NMR Assignments
Volume3
Issue number1
DOIs
Publication statusPublished - 2009 Jun
Externally publishedYes

Fingerprint

G Protein-Coupled Inwardly-Rectifying Potassium Channels
Inwardly Rectifying Potassium Channel
Heterotrimeric GTP-Binding Proteins
Protein Subunits
Eukaryotic Cells
GTP-Binding Proteins
Heart Rate
Molecular Weight
Molecular weight
Ligands

Keywords

  • GIRK
  • Inwardly rectifying potassium channel
  • Ion transport
  • Tetramer

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

Cite this

Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1). / Yokogawa, Mariko; Muramatsu, Takahiro; Takeuchi, Koh; Osawa, Masanori; Shimada, Ichio.

In: Biomolecular NMR Assignments, Vol. 3, No. 1, 06.2009, p. 125-128.

Research output: Contribution to journalArticle

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