Backbone resonance assignments for the cytoplasmic regions of G protein-activated inwardly rectifying potassium channel 1 (GIRK1)

Mariko Yokogawa, Takahiro Muramatsu, Koh Takeuchi, Masanori Osawa, Ichio Shimada

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

G protein-activated inwardly rectifying potassium channel (GIRK) plays crucial roles in regulating heart rate and neuronal excitability in eukaryotic cells. A variety of ligands, including heterotrimeric G protein βγ subunits (Gβγ), bind to the cytoplasmic regions of GIRK and modulate its activity. We established the backbone resonance assignments of 2H/13C/15N-labeled cytoplasmic regions of mouse GIRK1, which form a tetramer with a molecular weight of 96 K.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalBiomolecular NMR Assignments
Volume3
Issue number1
DOIs
Publication statusPublished - 2009 Jun 1
Externally publishedYes

Keywords

  • GIRK
  • Inwardly rectifying potassium channel
  • Ion transport
  • Tetramer

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

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