Bacterial pneumonia-induced persistent remission of severe immune thrombocytopenia after Allogeneic hematopoietic stem cell transplantation

Makoto Onizuka; Hiromichi Matsushita; Shinichiro Machida; Masako Toyosaki; Jun Amaki; Yasuyuki Aoyama; Mitsuki Miyamoto; Kiyoshi Ando

doi:10.2169/internalmedicine.55.4724

Bacterial pneumonia-induced persistent remission of severe immune thrombocytopenia after Allogeneic hematopoietic stem cell transplantation

Makoto Onizuka, Hiromichi Matsushita, Shinichiro Machida, Masako Toyosaki, Jun Amaki, Yasuyuki Aoyama, Mitsuki Miyamoto, Kiyoshi Ando

Research output: Contribution to journal › Article › peer-review

Abstract

A 53-year-old woman with chronic myeloid leukemia received allogeneic hematopoietic stem cell transplantation. After neutrophil engraftment, her platelet count exceeded 100,000/μL at day 64. While she was receiving corticosteroid treatment for chronic graft versus host disease (GVHD), her platelets suddenly dropped to 6,000/μL at day 210 and she was diagnosed with immune thrombocytopenia (ITP). Corticosteroids, intravenous high-dose gamma globulin (IVIg) and a splenectomy failed to increase her platelet count. She developed bacterial pneumonia at day 599 and antibiotic therapy was initiated. Soon after, her platelet count continuously increased. Her GVHD and ITP are now in remission without any ongoing treatment.

Original language	English
Pages (from-to)	179-183
Number of pages	5
Journal	Internal Medicine
Volume	55
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.55.4724
Publication status	Published - 2016 Jan 15
Externally published	Yes

Keywords

Allogeneic stem cell transplantation
CML
GVHD
Infection
ITP

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.55.4724

Cite this

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title = "Bacterial pneumonia-induced persistent remission of severe immune thrombocytopenia after Allogeneic hematopoietic stem cell transplantation",

abstract = "A 53-year-old woman with chronic myeloid leukemia received allogeneic hematopoietic stem cell transplantation. After neutrophil engraftment, her platelet count exceeded 100,000/μL at day 64. While she was receiving corticosteroid treatment for chronic graft versus host disease (GVHD), her platelets suddenly dropped to 6,000/μL at day 210 and she was diagnosed with immune thrombocytopenia (ITP). Corticosteroids, intravenous high-dose gamma globulin (IVIg) and a splenectomy failed to increase her platelet count. She developed bacterial pneumonia at day 599 and antibiotic therapy was initiated. Soon after, her platelet count continuously increased. Her GVHD and ITP are now in remission without any ongoing treatment.",

keywords = "Allogeneic stem cell transplantation, CML, GVHD, Infection, ITP",

author = "Makoto Onizuka and Hiromichi Matsushita and Shinichiro Machida and Masako Toyosaki and Jun Amaki and Yasuyuki Aoyama and Mitsuki Miyamoto and Kiyoshi Ando",

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AU - Onizuka, Makoto

AU - Matsushita, Hiromichi

AU - Machida, Shinichiro

AU - Toyosaki, Masako

AU - Amaki, Jun

AU - Aoyama, Yasuyuki

AU - Miyamoto, Mitsuki

AU - Ando, Kiyoshi

PY - 2016/1/15

Y1 - 2016/1/15

N2 - A 53-year-old woman with chronic myeloid leukemia received allogeneic hematopoietic stem cell transplantation. After neutrophil engraftment, her platelet count exceeded 100,000/μL at day 64. While she was receiving corticosteroid treatment for chronic graft versus host disease (GVHD), her platelets suddenly dropped to 6,000/μL at day 210 and she was diagnosed with immune thrombocytopenia (ITP). Corticosteroids, intravenous high-dose gamma globulin (IVIg) and a splenectomy failed to increase her platelet count. She developed bacterial pneumonia at day 599 and antibiotic therapy was initiated. Soon after, her platelet count continuously increased. Her GVHD and ITP are now in remission without any ongoing treatment.

AB - A 53-year-old woman with chronic myeloid leukemia received allogeneic hematopoietic stem cell transplantation. After neutrophil engraftment, her platelet count exceeded 100,000/μL at day 64. While she was receiving corticosteroid treatment for chronic graft versus host disease (GVHD), her platelets suddenly dropped to 6,000/μL at day 210 and she was diagnosed with immune thrombocytopenia (ITP). Corticosteroids, intravenous high-dose gamma globulin (IVIg) and a splenectomy failed to increase her platelet count. She developed bacterial pneumonia at day 599 and antibiotic therapy was initiated. Soon after, her platelet count continuously increased. Her GVHD and ITP are now in remission without any ongoing treatment.

KW - Allogeneic stem cell transplantation

KW - CML

KW - GVHD

KW - Infection

KW - ITP

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Bacterial pneumonia-induced persistent remission of severe immune thrombocytopenia after Allogeneic hematopoietic stem cell transplantation

Abstract

Keywords

ASJC Scopus subject areas

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