OBJECTIVE: To study the cytomorphologic features of bar-shaped chromatin in conjunctival samples and assess whether there are morphologic similarities between nuclear grooves seen in thyroid papillary carcinoma and bar-shaped chromatin. STUDY DESIGN: A total of 10 conjunctival samples from five volunteers were studied cytologically. Of the 10 samples, 2 showed bar- shaped chromatin. This chromatin was studied using a light microscope, scanning electron microscope (SEM) and transmission electron microscope (TEM). RESULTS: On SEM, bar-shaped chromatin was observed as a fissure or shallow cracks. On TEM the bar-shaped chromatin existed both in the center of the nuclei and in the nuclear membrane and cytoplasm. It was surrounded by outer and inner membranes. CONCLUSION: It seems that bar-shaped chromatin is formed by the nuclear membrane and that these changes are essentially the same configuration as cytoplasmic invaginations commonly present in papillary carcinoma of the thyroid.
- Bar-shaped chromatin
- Conjunctival smears
- Electron microscopy
ASJC Scopus subject areas
- Pathology and Forensic Medicine