Baroreceptor sensitivity during the compensatory phase of left ventricular overloading

Hiroshi Nishimura, Tsutomu Yoshikawa, Toshihisa Anzai, Akiyasu Baba, Natsuki Kobayashi, Yumiko Wainai, Satoshi Ogawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study focused on the role of the baroreceptor-mediated control during the compensatory process after acute left ventricular overloading induced by aortic regurgitation (AR). Baroreceptor-heart rate sensitivity was measured using a phenylephrine-induced increase in blood pressure according to the steady state method before, 1 day, 1 week and 4 weeks after production of AR in 7 rabbits, and compared with 6 other rabbits that underwent a sham operation. Blood pressure was monitored noninvasively using Finapres in the unanesthetized state. Four weeks after the procedure, the left ventricular diameters of both end-diastole and end-systole were larger in the rabbits with AR than in the sham-operated rabbits. There was no difference in the left ventricular end-diastolic pressure or cardiac output. Left ventricular weight was higher in the rabbits with AR than in the sham-operated rabbits. Myocardial β-adrenergic receptor density and norepinephrine content were comparable between the two groups. Baroreceptor-heart rate sensitivity significantly decreased 1 week after production of AR, and this alteration in sensitivity was partially restored 4 weeks after production of AR. These findings suggested that the altered baroreceptor-heart rate sensitivity was reversible, relating to the compensatory process after acute left ventricular overloading, and that these changes had some role in its pathophysiology.

Original languageEnglish
Pages (from-to)773-778
Number of pages6
JournalJapanese Circulation Journal
Volume62
Issue number10
DOIs
Publication statusPublished - 1998 Oct

Fingerprint

Pressoreceptors
Aortic Valve Insufficiency
Rabbits
Heart Rate
Blood Pressure
Diastole
Systole
Phenylephrine
Cardiac Output
Adrenergic Receptors
Norepinephrine
Weights and Measures

Keywords

  • β-Adrenergic receptor
  • Aortic regurgitation
  • Baroreceptor sensitivity
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Nishimura, H., Yoshikawa, T., Anzai, T., Baba, A., Kobayashi, N., Wainai, Y., & Ogawa, S. (1998). Baroreceptor sensitivity during the compensatory phase of left ventricular overloading. Japanese Circulation Journal, 62(10), 773-778. https://doi.org/10.1253/jcj.62.773

Baroreceptor sensitivity during the compensatory phase of left ventricular overloading. / Nishimura, Hiroshi; Yoshikawa, Tsutomu; Anzai, Toshihisa; Baba, Akiyasu; Kobayashi, Natsuki; Wainai, Yumiko; Ogawa, Satoshi.

In: Japanese Circulation Journal, Vol. 62, No. 10, 10.1998, p. 773-778.

Research output: Contribution to journalArticle

Nishimura, H, Yoshikawa, T, Anzai, T, Baba, A, Kobayashi, N, Wainai, Y & Ogawa, S 1998, 'Baroreceptor sensitivity during the compensatory phase of left ventricular overloading', Japanese Circulation Journal, vol. 62, no. 10, pp. 773-778. https://doi.org/10.1253/jcj.62.773
Nishimura, Hiroshi ; Yoshikawa, Tsutomu ; Anzai, Toshihisa ; Baba, Akiyasu ; Kobayashi, Natsuki ; Wainai, Yumiko ; Ogawa, Satoshi. / Baroreceptor sensitivity during the compensatory phase of left ventricular overloading. In: Japanese Circulation Journal. 1998 ; Vol. 62, No. 10. pp. 773-778.
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