Baseline plasma aldosterone level and renin activity allowing omission of confirmatory testing in primary aldosteronism

Junji Kawashima, Eiichi Araki, Mitsuhide Naruse, Isao Kurihara, Katsutoshi Takahashi, Kouichi Tamura, Hiroki Kobayashi, Shintaro Okamura, Shozo Miyauchi, Koichi Yamamoto, Shoichiro Izawa, Tomoko Suzuki, Akiyo Tanabe

Research output: Contribution to journalArticle

Abstract

Context: Previous studies have proposed cutoff value of baseline plasma aldosterone concentration (bPAC) under renin suppression that could diagnose primary aldosteronism (PA) without confirmatory testing. However, those studies are limited by selection bias due to a small number of patients and a single-center study design. Objective: This study aimed to determine cutoff value of bPAC and baseline plasma renin activity (bPRA) for predicting positive results in confirmatory tests for PA. Design: The multi-institutional, retrospective, cohort study was conducted using the PA registry in Japan (JPAS/JRAS). We compared bPAC in patients with PA who showed positive and negative captopril challenge test (CCT) or saline infusion test (SIT) results. Patients: Patients with PA who underwent CCT (n = 2256) and/or SIT (n = 1184) were studied. Main outcome measures: The main outcomes were cutoff value of bPAC (ng/dL) and bPRA (ng/mL/h) for predicting positive CCT and/or SIT results. Results: In patients with renin suppression (bPRA ≤ 0.3), the cutoff value of bPAC that would give 100% specificity for predicting a positive SIT result was lower than that for predicting a positive CCT result (30.85 vs 56.35, respectively). Specificities of bPAC cutoff values ≥ 30.85 for predicting positive SIT and CCT results remained high (100.0% and 97.0%, respectively) in patients with bPRA ≤ 0.6. However, the specificities of bPAC cutoff values ≥ 30.85 for predicting positive SIT and CCT results decreased when patients with bPRA > 0.6 were included. Conclusion: Confirmatory testing could be omitted in patients with bPAC ≥ 30.85 in the presence of bPRA ≤ 0.6.

Original languageEnglish
Article numberdgaa117
JournalJournal of Clinical Endocrinology and Metabolism
Volume105
Issue number5
DOIs
Publication statusPublished - 2020 May 1

Keywords

  • ARR
  • Aldosterone
  • Primary aldosteronism
  • Rennin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Kawashima, J., Araki, E., Naruse, M., Kurihara, I., Takahashi, K., Tamura, K., Kobayashi, H., Okamura, S., Miyauchi, S., Yamamoto, K., Izawa, S., Suzuki, T., & Tanabe, A. (2020). Baseline plasma aldosterone level and renin activity allowing omission of confirmatory testing in primary aldosteronism. Journal of Clinical Endocrinology and Metabolism, 105(5), [dgaa117]. https://doi.org/10.1210/clinem/dgaa117