Basic design and synthesis of sulfonated contrast agents for magnetic resonance imaging based on gadolinium complexes

Hiroki Hifumi, Akihiro Tanimoto, Aki Honda, Daniel Citterio, Koji Suzuki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Magnetic resonance angiography (MRA) is an imaging method to examine blood vessels based on the magnetic resonance imaging (MRI) technique. For this purpose, blood pool contrast agents have been developed to selectively increase the signal intensity of the intravascular lumen for improvement of the contrast-to-noise ratio in MR images. Here, we describe the design and the syntheses of six novel sulfonated contrast agents (KMR-Sulfo1 - 6), their chemical properties and their in vivo applications. In this study, we investigated the lipophilicity and the hydrophilicity of a gadolinium complex using a convenient two-step synthesis route, with the goal of prolonging the plasma half-life by binding mainly to human serum albumin. We confirmed that KMR-Sulfo5 fulfilled the requirements as a blood pool contrast agent: it showed a sufficient relaxivity r 1 of 5.9 mM -1 s -1 , a long plasma half-life of 25.7 min and complete elimination from the body within 12 h after the administration. 2007

Original languageEnglish
Pages (from-to)1159-1165
Number of pages7
Journalanalytical sciences
Volume23
Issue number10
DOIs
Publication statusPublished - 2007 Oct

ASJC Scopus subject areas

  • Analytical Chemistry

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