Basic studies on the stability of flavored oral solutions of rebamipide

Ryo Yajima, Futa Imaoka, Tetsuya Wako, Yuko Kuroda, Kazuaki Matsumoto, Junko Kizu, Shiro Katayama

Research output: Contribution to journalArticle

Abstract

Stomatitis frequently occurs during chemotherapy and radiotherapy for cancer. Because of its pharmacological properties including anti-inflammatory activity and stimulatory effects on endogenous prostaglandin synthesis, rebamipide has been suggested as a potentially effective treatment against stomatitis. In the present study we tested the stability of oral rebamipide solutions prepared in our hospital pharmacy using sodium alginate as a thickener to increase retention of this agent in the oral cavity, and the addition of different flavoring mixtures intended for use in enteral diets to reduce the bitterness of rebamipide and sodium alginate. Samples of oral rebamipide solution prepared with 13 kinds of flavoring and sodium alginate were evaluated in terms of their appearance, redispersibility, pH, viscosity, and rebamipide content immediately after preparation and 1, 3, 7, and 10 days after storage at room temperature under ambient light or in a cool, dark place. After 10 days of storage, favorable stability was observed in four sample solutions supplemented with green apple, pineapple, yogurt, and tomato flavoring mixtures intended for use in Elental® diets. These oral solutions may have potential clinical application.

Original languageEnglish
Pages (from-to)1397-1402
Number of pages6
JournalYakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Volume135
Issue number12
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Stomatitis
Ananas
Diet
Yogurt
Malus
Lycopersicon esculentum
Viscosity
Small Intestine
Prostaglandins
Mouth
Anti-Inflammatory Agents
Radiotherapy
rebamipide
Pharmacology
Light
Drug Therapy
Temperature
alginic acid
Neoplasms
Therapeutics

Keywords

  • Flavor
  • Rebamipide
  • Sodium alginate
  • Stability
  • Stomatitis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Basic studies on the stability of flavored oral solutions of rebamipide. / Yajima, Ryo; Imaoka, Futa; Wako, Tetsuya; Kuroda, Yuko; Matsumoto, Kazuaki; Kizu, Junko; Katayama, Shiro.

In: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, Vol. 135, No. 12, 01.12.2015, p. 1397-1402.

Research output: Contribution to journalArticle

Yajima, Ryo ; Imaoka, Futa ; Wako, Tetsuya ; Kuroda, Yuko ; Matsumoto, Kazuaki ; Kizu, Junko ; Katayama, Shiro. / Basic studies on the stability of flavored oral solutions of rebamipide. In: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2015 ; Vol. 135, No. 12. pp. 1397-1402.
@article{e43dd0012dbe4d50b120a2bf1520fec3,
title = "Basic studies on the stability of flavored oral solutions of rebamipide",
abstract = "Stomatitis frequently occurs during chemotherapy and radiotherapy for cancer. Because of its pharmacological properties including anti-inflammatory activity and stimulatory effects on endogenous prostaglandin synthesis, rebamipide has been suggested as a potentially effective treatment against stomatitis. In the present study we tested the stability of oral rebamipide solutions prepared in our hospital pharmacy using sodium alginate as a thickener to increase retention of this agent in the oral cavity, and the addition of different flavoring mixtures intended for use in enteral diets to reduce the bitterness of rebamipide and sodium alginate. Samples of oral rebamipide solution prepared with 13 kinds of flavoring and sodium alginate were evaluated in terms of their appearance, redispersibility, pH, viscosity, and rebamipide content immediately after preparation and 1, 3, 7, and 10 days after storage at room temperature under ambient light or in a cool, dark place. After 10 days of storage, favorable stability was observed in four sample solutions supplemented with green apple, pineapple, yogurt, and tomato flavoring mixtures intended for use in Elental{\circledR} diets. These oral solutions may have potential clinical application.",
keywords = "Flavor, Rebamipide, Sodium alginate, Stability, Stomatitis",
author = "Ryo Yajima and Futa Imaoka and Tetsuya Wako and Yuko Kuroda and Kazuaki Matsumoto and Junko Kizu and Shiro Katayama",
year = "2015",
month = "12",
day = "1",
doi = "10.1248/yakushi.15-00177",
language = "English",
volume = "135",
pages = "1397--1402",
journal = "Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan",
issn = "0031-6903",
publisher = "Pharmaceutical Society of Japan",
number = "12",

}

TY - JOUR

T1 - Basic studies on the stability of flavored oral solutions of rebamipide

AU - Yajima, Ryo

AU - Imaoka, Futa

AU - Wako, Tetsuya

AU - Kuroda, Yuko

AU - Matsumoto, Kazuaki

AU - Kizu, Junko

AU - Katayama, Shiro

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Stomatitis frequently occurs during chemotherapy and radiotherapy for cancer. Because of its pharmacological properties including anti-inflammatory activity and stimulatory effects on endogenous prostaglandin synthesis, rebamipide has been suggested as a potentially effective treatment against stomatitis. In the present study we tested the stability of oral rebamipide solutions prepared in our hospital pharmacy using sodium alginate as a thickener to increase retention of this agent in the oral cavity, and the addition of different flavoring mixtures intended for use in enteral diets to reduce the bitterness of rebamipide and sodium alginate. Samples of oral rebamipide solution prepared with 13 kinds of flavoring and sodium alginate were evaluated in terms of their appearance, redispersibility, pH, viscosity, and rebamipide content immediately after preparation and 1, 3, 7, and 10 days after storage at room temperature under ambient light or in a cool, dark place. After 10 days of storage, favorable stability was observed in four sample solutions supplemented with green apple, pineapple, yogurt, and tomato flavoring mixtures intended for use in Elental® diets. These oral solutions may have potential clinical application.

AB - Stomatitis frequently occurs during chemotherapy and radiotherapy for cancer. Because of its pharmacological properties including anti-inflammatory activity and stimulatory effects on endogenous prostaglandin synthesis, rebamipide has been suggested as a potentially effective treatment against stomatitis. In the present study we tested the stability of oral rebamipide solutions prepared in our hospital pharmacy using sodium alginate as a thickener to increase retention of this agent in the oral cavity, and the addition of different flavoring mixtures intended for use in enteral diets to reduce the bitterness of rebamipide and sodium alginate. Samples of oral rebamipide solution prepared with 13 kinds of flavoring and sodium alginate were evaluated in terms of their appearance, redispersibility, pH, viscosity, and rebamipide content immediately after preparation and 1, 3, 7, and 10 days after storage at room temperature under ambient light or in a cool, dark place. After 10 days of storage, favorable stability was observed in four sample solutions supplemented with green apple, pineapple, yogurt, and tomato flavoring mixtures intended for use in Elental® diets. These oral solutions may have potential clinical application.

KW - Flavor

KW - Rebamipide

KW - Sodium alginate

KW - Stability

KW - Stomatitis

UR - http://www.scopus.com/inward/record.url?scp=84948968057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948968057&partnerID=8YFLogxK

U2 - 10.1248/yakushi.15-00177

DO - 10.1248/yakushi.15-00177

M3 - Article

C2 - 26632156

AN - SCOPUS:84948968057

VL - 135

SP - 1397

EP - 1402

JO - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

SN - 0031-6903

IS - 12

ER -