Abstract
Objective: A late evening snack improves the catabolic state in patients with advanced liver cirrhosis. We tested whether long-term (3 mo) late evening snacking that included a branched-chain amino acid (BCAA)-enriched nutrient mixture produces a better nutritional state and better quality of life than ordinary food in patients with hepatitis C virus-positive liver cirrhosis. Methods: In a multicenter, randomized study, 48 patients with liver cirrhosis received late-evening supplementation with the BCAA-enriched nutrient mixture or ordinary food, such as a rice ball or bread, for 3 mo. During the study period, each patient was instructed on energy and protein intake. Blood biochemical data, nitrogen balance, respiratory quotient, and health-related quality of life (Short Form 36 questionnaire) were evaluated at baseline and at the end of the study. Results: Total and late-evening energy intakes were similar in the two groups at 3 mo. Serum albumin level, nitrogen balance, and respiratory quotient were significantly improved by the BCAA mixture but not by ordinary food. The parameters of the Short Form 36 did not statistically significantly improve over 3 mo in either group. Conclusion: Long-term oral supplementation with a BCAA mixture is better than ordinary food in a late evening snack at improving the serum albumin level and the energy metabolism in patients with cirrhosis.
| Original language | English |
|---|---|
| Pages (from-to) | 113-120 |
| Number of pages | 8 |
| Journal | Nutrition |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2007 Feb |
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Keywords
- Branched-chain amino acid
- Late evening snack
- Liver cirrhosis
- Nutritional therapy
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Surgery
- Medicine (miscellaneous)
Cite this
BCAA-enriched snack improves nutritional state of cirrhosis. / Nakaya, Yutaka; Okita, Kiwamu; Suzuki, Kazuyuki; Moriwaki, Hisataka; Kato, Akinobu; Miwa, Yoshiyuki; Shiraishi, Koichi; Okuda, Hiroaki; Onji, Morikazu; Kanazawa, Hidenori; Tsubouchi, Hirohito; Kato, Shinzo; Kaito, Masahiko; Watanabe, Akiharu; Habu, Daiki; Ito, Susumu; Ishikawa, Tomohisa; Kawamura, Naohiro; Arakawa, Yasuyuki.
In: Nutrition, Vol. 23, No. 2, 02.2007, p. 113-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - BCAA-enriched snack improves nutritional state of cirrhosis
AU - Nakaya, Yutaka
AU - Okita, Kiwamu
AU - Suzuki, Kazuyuki
AU - Moriwaki, Hisataka
AU - Kato, Akinobu
AU - Miwa, Yoshiyuki
AU - Shiraishi, Koichi
AU - Okuda, Hiroaki
AU - Onji, Morikazu
AU - Kanazawa, Hidenori
AU - Tsubouchi, Hirohito
AU - Kato, Shinzo
AU - Kaito, Masahiko
AU - Watanabe, Akiharu
AU - Habu, Daiki
AU - Ito, Susumu
AU - Ishikawa, Tomohisa
AU - Kawamura, Naohiro
AU - Arakawa, Yasuyuki
PY - 2007/2
Y1 - 2007/2
N2 - Objective: A late evening snack improves the catabolic state in patients with advanced liver cirrhosis. We tested whether long-term (3 mo) late evening snacking that included a branched-chain amino acid (BCAA)-enriched nutrient mixture produces a better nutritional state and better quality of life than ordinary food in patients with hepatitis C virus-positive liver cirrhosis. Methods: In a multicenter, randomized study, 48 patients with liver cirrhosis received late-evening supplementation with the BCAA-enriched nutrient mixture or ordinary food, such as a rice ball or bread, for 3 mo. During the study period, each patient was instructed on energy and protein intake. Blood biochemical data, nitrogen balance, respiratory quotient, and health-related quality of life (Short Form 36 questionnaire) were evaluated at baseline and at the end of the study. Results: Total and late-evening energy intakes were similar in the two groups at 3 mo. Serum albumin level, nitrogen balance, and respiratory quotient were significantly improved by the BCAA mixture but not by ordinary food. The parameters of the Short Form 36 did not statistically significantly improve over 3 mo in either group. Conclusion: Long-term oral supplementation with a BCAA mixture is better than ordinary food in a late evening snack at improving the serum albumin level and the energy metabolism in patients with cirrhosis.
AB - Objective: A late evening snack improves the catabolic state in patients with advanced liver cirrhosis. We tested whether long-term (3 mo) late evening snacking that included a branched-chain amino acid (BCAA)-enriched nutrient mixture produces a better nutritional state and better quality of life than ordinary food in patients with hepatitis C virus-positive liver cirrhosis. Methods: In a multicenter, randomized study, 48 patients with liver cirrhosis received late-evening supplementation with the BCAA-enriched nutrient mixture or ordinary food, such as a rice ball or bread, for 3 mo. During the study period, each patient was instructed on energy and protein intake. Blood biochemical data, nitrogen balance, respiratory quotient, and health-related quality of life (Short Form 36 questionnaire) were evaluated at baseline and at the end of the study. Results: Total and late-evening energy intakes were similar in the two groups at 3 mo. Serum albumin level, nitrogen balance, and respiratory quotient were significantly improved by the BCAA mixture but not by ordinary food. The parameters of the Short Form 36 did not statistically significantly improve over 3 mo in either group. Conclusion: Long-term oral supplementation with a BCAA mixture is better than ordinary food in a late evening snack at improving the serum albumin level and the energy metabolism in patients with cirrhosis.
KW - Branched-chain amino acid
KW - Late evening snack
KW - Liver cirrhosis
KW - Nutritional therapy
UR - http://www.scopus.com/inward/record.url?scp=33846206486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846206486&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2006.10.008
DO - 10.1016/j.nut.2006.10.008
M3 - Article
C2 - 17234504
AN - SCOPUS:33846206486
VL - 23
SP - 113
EP - 120
JO - Nutrition
JF - Nutrition
SN - 0899-9007
IS - 2
ER -