Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells

Y. Matsumoto, M. Kawatani, Siro Simizu, T. Tanaka, M. Takada, Masaya Imoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The broad-spectrum antagonist of neuropeptide receptor, [D-Arg1, D-Phe5, D-Trp7,9, Leu17]substance P, induced apoptosis selectively in human small cell lung carcinoma (SCLC) cells, which express gastrin-releasing peptide receptor, but not in other types of tumor cells as well as normal cells. The addition of gastrin-releasing peptide or bombesin and the inhibitor of caspase-3 suppressed [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis. Moreover, [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis was not suppressed by Bcl-2 over-expression. Thus, blockage of gastrin-releasing peptide receptor-mediated signaling may provide a novel therapeutic option in SCLC which has become resistant to conventional chemotherapeutic agents.

Original languageEnglish
Pages (from-to)3123-3129
Number of pages7
JournalAnticancer Research
Volume20
Issue number5
Publication statusPublished - 2000

    Fingerprint

Keywords

  • Apoptosis
  • Bcl-2
  • Gastrin-releasing peptide
  • Small cell lung carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this