Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells

Y. Matsumoto, M. Kawatani, Siro Simizu, T. Tanaka, M. Takada, Masaya Imoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The broad-spectrum antagonist of neuropeptide receptor, [D-Arg1, D-Phe5, D-Trp7,9, Leu17]substance P, induced apoptosis selectively in human small cell lung carcinoma (SCLC) cells, which express gastrin-releasing peptide receptor, but not in other types of tumor cells as well as normal cells. The addition of gastrin-releasing peptide or bombesin and the inhibitor of caspase-3 suppressed [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis. Moreover, [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis was not suppressed by Bcl-2 over-expression. Thus, blockage of gastrin-releasing peptide receptor-mediated signaling may provide a novel therapeutic option in SCLC which has become resistant to conventional chemotherapeutic agents.

Original languageEnglish
Pages (from-to)3123-3129
Number of pages7
JournalAnticancer Research
Volume20
Issue number5
Publication statusPublished - 2000

Fingerprint

Neuropeptide Receptors
Small Cell Lung Carcinoma
Substance P
Bombesin Receptors
Apoptosis
Gastrin-Releasing Peptide
Bombesin
Caspase 3
Neoplasms
Therapeutics

Keywords

  • Apoptosis
  • Bcl-2
  • Gastrin-releasing peptide
  • Small cell lung carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells. / Matsumoto, Y.; Kawatani, M.; Simizu, Siro; Tanaka, T.; Takada, M.; Imoto, Masaya.

In: Anticancer Research, Vol. 20, No. 5, 2000, p. 3123-3129.

Research output: Contribution to journalArticle

@article{df740a916dab478699c43e10a47dac01,
title = "Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells",
abstract = "The broad-spectrum antagonist of neuropeptide receptor, [D-Arg1, D-Phe5, D-Trp7,9, Leu17]substance P, induced apoptosis selectively in human small cell lung carcinoma (SCLC) cells, which express gastrin-releasing peptide receptor, but not in other types of tumor cells as well as normal cells. The addition of gastrin-releasing peptide or bombesin and the inhibitor of caspase-3 suppressed [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis. Moreover, [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis was not suppressed by Bcl-2 over-expression. Thus, blockage of gastrin-releasing peptide receptor-mediated signaling may provide a novel therapeutic option in SCLC which has become resistant to conventional chemotherapeutic agents.",
keywords = "Apoptosis, Bcl-2, Gastrin-releasing peptide, Small cell lung carcinoma",
author = "Y. Matsumoto and M. Kawatani and Siro Simizu and T. Tanaka and M. Takada and Masaya Imoto",
year = "2000",
language = "English",
volume = "20",
pages = "3123--3129",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

TY - JOUR

T1 - Bcl-2-independent induction of apoptosis by neuropeptide receptor antagonist in human small cell lung carcinoma cells

AU - Matsumoto, Y.

AU - Kawatani, M.

AU - Simizu, Siro

AU - Tanaka, T.

AU - Takada, M.

AU - Imoto, Masaya

PY - 2000

Y1 - 2000

N2 - The broad-spectrum antagonist of neuropeptide receptor, [D-Arg1, D-Phe5, D-Trp7,9, Leu17]substance P, induced apoptosis selectively in human small cell lung carcinoma (SCLC) cells, which express gastrin-releasing peptide receptor, but not in other types of tumor cells as well as normal cells. The addition of gastrin-releasing peptide or bombesin and the inhibitor of caspase-3 suppressed [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis. Moreover, [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis was not suppressed by Bcl-2 over-expression. Thus, blockage of gastrin-releasing peptide receptor-mediated signaling may provide a novel therapeutic option in SCLC which has become resistant to conventional chemotherapeutic agents.

AB - The broad-spectrum antagonist of neuropeptide receptor, [D-Arg1, D-Phe5, D-Trp7,9, Leu17]substance P, induced apoptosis selectively in human small cell lung carcinoma (SCLC) cells, which express gastrin-releasing peptide receptor, but not in other types of tumor cells as well as normal cells. The addition of gastrin-releasing peptide or bombesin and the inhibitor of caspase-3 suppressed [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis. Moreover, [D-Arg1, D-Phe5, D-Trp7,9, Leu11]substance P-induced apoptosis was not suppressed by Bcl-2 over-expression. Thus, blockage of gastrin-releasing peptide receptor-mediated signaling may provide a novel therapeutic option in SCLC which has become resistant to conventional chemotherapeutic agents.

KW - Apoptosis

KW - Bcl-2

KW - Gastrin-releasing peptide

KW - Small cell lung carcinoma

UR - http://www.scopus.com/inward/record.url?scp=0033785521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033785521&partnerID=8YFLogxK

M3 - Article

C2 - 11062732

AN - SCOPUS:0033785521

VL - 20

SP - 3123

EP - 3129

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 5

ER -