Bead-based rapid construction of heterogeneous 3D tissue architecture

Yukiko Tsuda, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This paper describes a method to construct macroscopic heterogeneous 3D tissue architecture by molding bead based micro-tissue units, so called "cell beads". We prepared mass-producible monodisperse collagen micro-gel beads coated with cells that we could stack into a mold to produce large-scale tissues rapidly with uniform cell density (Fig. 1). By using different types of cell beads or assembling macroscopic tissues prepared from the different cell types of beads, heterogeneous 3D tissue architecture was easily prepared. This approach would enable the rapid and reproducible construction of large-scale 3D tissues with a complex microstructure.

Original languageEnglish
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages2014-2016
Number of pages3
Publication statusPublished - 2010 Dec 1
Externally publishedYes
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: 2010 Oct 32010 Oct 7

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume3

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Country/TerritoryNetherlands
CityGroningen
Period10/10/310/10/7

Keywords

  • 3D tissue
  • Co-culture system
  • Collagen
  • Micro-beads
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering

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