Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia

Teruhito Okumura, Yoshinori Gonda, Koji Ioku, Masanobu Kamitakahara, Takatoshi Okuda, Ikuho Yonezawa, Hisashi Kurosawa, Izumi Asahina, Tohru Ikeda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalNippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
Volume119
Issue number1386
Publication statusPublished - 2011 Feb
Externally publishedYes

Fingerprint

tibia
bones
rats
Rats
phosphates
Bone
Phosphates
rods
implantation
phosphatases
bone marrow
Phosphatases
defects
Defects
Cells
healing
Tissue
regeneration
tricalcium phosphate
routes

Keywords

  • Alkaline phosphatase
  • Beta-tricalcium phosphate
  • Bone substitute
  • Healing of bone defect
  • Hydrothermal route

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry
  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia. / Okumura, Teruhito; Gonda, Yoshinori; Ioku, Koji; Kamitakahara, Masanobu; Okuda, Takatoshi; Yonezawa, Ikuho; Kurosawa, Hisashi; Asahina, Izumi; Ikeda, Tohru.

In: Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan, Vol. 119, No. 1386, 02.2011, p. 101-104.

Research output: Contribution to journalArticle

Okumura, T, Gonda, Y, Ioku, K, Kamitakahara, M, Okuda, T, Yonezawa, I, Kurosawa, H, Asahina, I & Ikeda, T 2011, 'Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia', Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan, vol. 119, no. 1386, pp. 101-104.
Okumura, Teruhito ; Gonda, Yoshinori ; Ioku, Koji ; Kamitakahara, Masanobu ; Okuda, Takatoshi ; Yonezawa, Ikuho ; Kurosawa, Hisashi ; Asahina, Izumi ; Ikeda, Tohru. / Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia. In: Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan. 2011 ; Vol. 119, No. 1386. pp. 101-104.
@article{69372e2e3bc44612b7fdfcc6246a730c,
title = "Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia",
abstract = "Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.",
keywords = "Alkaline phosphatase, Beta-tricalcium phosphate, Bone substitute, Healing of bone defect, Hydrothermal route",
author = "Teruhito Okumura and Yoshinori Gonda and Koji Ioku and Masanobu Kamitakahara and Takatoshi Okuda and Ikuho Yonezawa and Hisashi Kurosawa and Izumi Asahina and Tohru Ikeda",
year = "2011",
month = "2",
language = "English",
volume = "119",
pages = "101--104",
journal = "Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan",
issn = "0914-5400",
publisher = "Ceramic Society of Japan/Nippon Seramikkusu Kyokai",
number = "1386",

}

TY - JOUR

T1 - Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia

AU - Okumura, Teruhito

AU - Gonda, Yoshinori

AU - Ioku, Koji

AU - Kamitakahara, Masanobu

AU - Okuda, Takatoshi

AU - Yonezawa, Ikuho

AU - Kurosawa, Hisashi

AU - Asahina, Izumi

AU - Ikeda, Tohru

PY - 2011/2

Y1 - 2011/2

N2 - Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.

AB - Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.

KW - Alkaline phosphatase

KW - Beta-tricalcium phosphate

KW - Bone substitute

KW - Healing of bone defect

KW - Hydrothermal route

UR - http://www.scopus.com/inward/record.url?scp=79551656487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551656487&partnerID=8YFLogxK

M3 - Article

VL - 119

SP - 101

EP - 104

JO - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan

JF - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan

SN - 0914-5400

IS - 1386

ER -