TY - JOUR
T1 - Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia
AU - Okumura, Teruhito
AU - Gonda, Yoshinori
AU - Ioku, Koji
AU - Kamitakahara, Masanobu
AU - Okuda, Takatoshi
AU - Yonezawa, Ikuho
AU - Kurosawa, Hisashi
AU - Asahina, Izumi
AU - Ikeda, Tohru
PY - 2011/2
Y1 - 2011/2
N2 - Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.
AB - Porous spherical granules of β-tricalcium phosphate (β3-TCP) composed of rod-shaped particles were prepared viaa hydrothermal route. The biological significance ofimplantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created intibiae of 9-week-oldWistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residualimplants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer intibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted granules worked as scaffolds to maintainalkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.
KW - Alkaline phosphatase
KW - Beta-tricalcium phosphate
KW - Bone substitute
KW - Healing of bone defect
KW - Hydrothermal route
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U2 - 10.2109/jcersj2.119.101
DO - 10.2109/jcersj2.119.101
M3 - Article
AN - SCOPUS:79551656487
SN - 0914-5400
VL - 119
SP - 101
EP - 104
JO - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
JF - Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
IS - 1386
ER -