Behavior of nanoparticles in extended nanospace measured by evanescent wave-based particle velocimetry

Yutaka Kazoe, Kazuma Mawatari, Takehiko Kitamori

Research output: Contribution to journalArticle

14 Citations (Scopus)


The transport and behavior of nanoparticles, viruses, and biomacromolecules in 10-1000 nm confined spaces (hereafter extended nanospaces) are important for novel analytical devices based on nanofluidics. This study investigated the concentration and diffusion of 64 nm nanoparticles in a fused-silica nanochannel of 410 nm depth, using evanescent wave-based particle velocimetry. We found that the injection of nanoparticles into the nanochannel by pressure-driven flow was significantly inhibited and that the nanoparticle diffusion was hindered anisotropically. A 0.2-pN repulsive force induced by the interaction between the nanoparticles and the channel wall is proposed as the dominant factor governing the behavior of nanoparticles in the nanochannel, on the basis of both experimental measurements and theoretical estimations. The results of this study will greatly further our understanding of mass transfer in extended nanospaces.

Original languageEnglish
Pages (from-to)4087-4091
Number of pages5
JournalAnalytical chemistry
Issue number8
Publication statusPublished - 2015 Apr 21
Externally publishedYes


ASJC Scopus subject areas

  • Analytical Chemistry

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