Beneficial effect of atorvastatin on renal function in patients with type 2 diabetes

M. Tanaka

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two studies investigated the effect of atorvastatin on glycaemic control and renal function in patients with type 2 diabetes. In study 1, 27 outpatients with hypercholesterolaemia (16 statin-naïve, 11 switched from another statin) took atorvastatin (10 mg once daily) for 3 months. After 3 months, low-density lipo - protein cholesterol (LDL-C) had decreased significantly in both groups, high-density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate had increased only in the statin-naïve group, and glycosylated haemoglobin (HbA1c) had not changed significantly in either group. Study 2 was a retrospective investigation of 87 outpatients with hyper cholesterolaemia who had been taking atorvastatin for at least 4 years. Compared with baseline (patients who had taken atorvastatin for at least 1 year), total cholesterol and triglyceride levels did not change over the study period, HDL-C increased significantly at 2 and 3 years, HbA1c was significantly decreased at 1, 2 and 3 years and serum creatinine was significantly decreased at 1 year. Atorvastatin lowered LDL-C concentration, did not worsen glycaemic control and might improve renal function in patients with type 2 diabetes.

Original languageEnglish
Pages (from-to)1504-1512
Number of pages9
JournalJournal of International Medical Research
Volume39
Issue number4
DOIs
Publication statusPublished - 2011 Jan 1
Externally publishedYes

Keywords

  • 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors
  • Atorvastatin
  • Glycaemic control
  • Hypercholesterolaemia
  • Renal function
  • Statins
  • Type 2 diabetes

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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