Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats

Nanako Muraya, Daisuke Kadowaki, Shigeyuki Miyamura, Kenichiro Kitamura, Kohei Uchimura, Yuki Narita, Yohei Miyamoto, Victor Tuan Giam Chuang, Kazuaki Taguchi, Toru Maruyama, Masaki Otagiri, Sumio Hirata

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We previously found that benzbromarone, a uricosuric agent, has a direct free radical scavenging effect in vitro. The antioxidant effects of benzbromarone were evaluated in vivo via oral administration of benzbromarone for 4 weeks to model rats with angiotensin II- and salt-induced hypertension. Benzbromarone did not alter plasma uric acid levels or blood pressure but significantly reduced the levels of advanced oxidation protein products, which are oxidative stress markers. Furthermore, dihydroethidium staining of the kidney revealed a reduction in oxidative stress after benzbromarone administration. These results suggest that benzbromarone has a direct antioxidant effect in vivo and great potential to prevent CVD and CKD.

Original languageEnglish
Number of pages1
JournalOxidative Medicine and Cellular Longevity
Volume2018
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Fingerprint

Benzbromarone
Oxidative stress
Angiotensin II
Rats
Oxidative Stress
Salts
Hyperuricemia
Chronic Renal Insufficiency
Uricosuric Agents
Cardiovascular Diseases
Advanced Oxidation Protein Products
Antioxidants
Scavenging
Blood pressure
Angiotensins
Renin-Angiotensin System
Uric Acid
Renin
Free Radicals
Oral Administration

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

Cite this

Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. / Muraya, Nanako; Kadowaki, Daisuke; Miyamura, Shigeyuki; Kitamura, Kenichiro; Uchimura, Kohei; Narita, Yuki; Miyamoto, Yohei; Chuang, Victor Tuan Giam; Taguchi, Kazuaki; Maruyama, Toru; Otagiri, Masaki; Hirata, Sumio.

In: Oxidative Medicine and Cellular Longevity, Vol. 2018, 01.01.2018.

Research output: Contribution to journalArticle

Muraya, N, Kadowaki, D, Miyamura, S, Kitamura, K, Uchimura, K, Narita, Y, Miyamoto, Y, Chuang, VTG, Taguchi, K, Maruyama, T, Otagiri, M & Hirata, S 2018, 'Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats', Oxidative Medicine and Cellular Longevity, vol. 2018. https://doi.org/10.1155/2018/7635274
Muraya, Nanako ; Kadowaki, Daisuke ; Miyamura, Shigeyuki ; Kitamura, Kenichiro ; Uchimura, Kohei ; Narita, Yuki ; Miyamoto, Yohei ; Chuang, Victor Tuan Giam ; Taguchi, Kazuaki ; Maruyama, Toru ; Otagiri, Masaki ; Hirata, Sumio. / Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats. In: Oxidative Medicine and Cellular Longevity. 2018 ; Vol. 2018.
@article{5d6d28b01ab449f183e68748be66268a,
title = "Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats",
abstract = "Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We previously found that benzbromarone, a uricosuric agent, has a direct free radical scavenging effect in vitro. The antioxidant effects of benzbromarone were evaluated in vivo via oral administration of benzbromarone for 4 weeks to model rats with angiotensin II- and salt-induced hypertension. Benzbromarone did not alter plasma uric acid levels or blood pressure but significantly reduced the levels of advanced oxidation protein products, which are oxidative stress markers. Furthermore, dihydroethidium staining of the kidney revealed a reduction in oxidative stress after benzbromarone administration. These results suggest that benzbromarone has a direct antioxidant effect in vivo and great potential to prevent CVD and CKD.",
author = "Nanako Muraya and Daisuke Kadowaki and Shigeyuki Miyamura and Kenichiro Kitamura and Kohei Uchimura and Yuki Narita and Yohei Miyamoto and Chuang, {Victor Tuan Giam} and Kazuaki Taguchi and Toru Maruyama and Masaki Otagiri and Sumio Hirata",
year = "2018",
month = "1",
day = "1",
doi = "10.1155/2018/7635274",
language = "English",
volume = "2018",
journal = "Oxidative Medicine and Cellular Longevity",
issn = "1942-0900",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Benzbromarone Attenuates Oxidative Stress in Angiotensin II- and Salt-Induced Hypertensive Model Rats

AU - Muraya, Nanako

AU - Kadowaki, Daisuke

AU - Miyamura, Shigeyuki

AU - Kitamura, Kenichiro

AU - Uchimura, Kohei

AU - Narita, Yuki

AU - Miyamoto, Yohei

AU - Chuang, Victor Tuan Giam

AU - Taguchi, Kazuaki

AU - Maruyama, Toru

AU - Otagiri, Masaki

AU - Hirata, Sumio

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We previously found that benzbromarone, a uricosuric agent, has a direct free radical scavenging effect in vitro. The antioxidant effects of benzbromarone were evaluated in vivo via oral administration of benzbromarone for 4 weeks to model rats with angiotensin II- and salt-induced hypertension. Benzbromarone did not alter plasma uric acid levels or blood pressure but significantly reduced the levels of advanced oxidation protein products, which are oxidative stress markers. Furthermore, dihydroethidium staining of the kidney revealed a reduction in oxidative stress after benzbromarone administration. These results suggest that benzbromarone has a direct antioxidant effect in vivo and great potential to prevent CVD and CKD.

AB - Oxidative stress induced by hyperuricemia is closely associated with the renin-angiotensin system, as well as the onset and progression of cardiovascular disease (CVD) and chronic kidney disease (CKD). It is therefore important to reduce oxidative stress to treat hyperuricemia. We previously found that benzbromarone, a uricosuric agent, has a direct free radical scavenging effect in vitro. The antioxidant effects of benzbromarone were evaluated in vivo via oral administration of benzbromarone for 4 weeks to model rats with angiotensin II- and salt-induced hypertension. Benzbromarone did not alter plasma uric acid levels or blood pressure but significantly reduced the levels of advanced oxidation protein products, which are oxidative stress markers. Furthermore, dihydroethidium staining of the kidney revealed a reduction in oxidative stress after benzbromarone administration. These results suggest that benzbromarone has a direct antioxidant effect in vivo and great potential to prevent CVD and CKD.

UR - http://www.scopus.com/inward/record.url?scp=85055001370&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055001370&partnerID=8YFLogxK

U2 - 10.1155/2018/7635274

DO - 10.1155/2018/7635274

M3 - Article

VL - 2018

JO - Oxidative Medicine and Cellular Longevity

JF - Oxidative Medicine and Cellular Longevity

SN - 1942-0900

ER -