Beta-blockade prevents ventricular failure following aortic regurgitation in rabbits

Masahiro Suzuki, Tsutomu Yoshilcawa, Yumiko Wainaia, Keiichi Nagami, Shunnosuke Honda

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7 Citations (Scopus)

Abstract

This study investigated the effects of chronic β-blockade on the pathophysiology of heart failure following induction of aortic regurgitation (AR). Nine rabbits with AR were administered propranolol continuously for 7 days (AR+P), 8 rabbits with AR received vehicle for the same period (AR+C), and 7 rabbits underwent sham operation. Cardiac output was lower and the left-ventricular end-diastolic pressure was higher in AR+C than in sham-operated rabbits, but there was no difference in the right-ventricular end-diastolic pressure between the two groups. Down-regulation of β-adrenoceptors was observed in the left ventricle, but not in the right ventricle. All of these variables were reversed in AR+P. In left-ventricular failure produced by AR, (1) the augmentation of adrenergic drive occurred selectively in the left ventricle, and (2) propranolol blunted adrenergic drive and played a protective role against myocardial damage.

Original languageEnglish
Pages (from-to)418-424
Number of pages7
JournalCardiology (Switzerland)
Volume88
Issue number5
DOIs
Publication statusPublished - 1997 Jan 1

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Keywords

  • β-Adrenergic receptor
  • β-Blocker
  • Aortic regurgitation
  • Catecholamine
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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