Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tatsuya Nishihara, Satoshi Kuno, Hiroshi Nonaka, Sho Tabata, Natsumi Saito, Shinji Fukuda, Masaru Tomita, Shinsuke Sando, Tomoyoshi Soga

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

Original languageEnglish
Pages (from-to)11745-11748
Number of pages4
JournalChemical Communications
Volume54
Issue number83
DOIs
Publication statusPublished - 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Nishihara, T., Kuno, S., Nonaka, H., Tabata, S., Saito, N., Fukuda, S., Tomita, M., Sando, S., & Soga, T. (2018). Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection. Chemical Communications, 54(83), 11745-11748. https://doi.org/10.1039/c8cc06068a