Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tatsuya Nishihara; Satoshi Kuno; Hiroshi Nonaka; Sho Tabata; Natsumi Saito; Shinji Fukuda; Masaru Tomita; Shinsuke Sando; Tomoyoshi Soga

doi:10.1039/c8cc06068a

Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tatsuya Nishihara, Satoshi Kuno, Hiroshi Nonaka, Sho Tabata, Natsumi Saito, Shinji Fukuda, Masaru Tomita, Shinsuke Sando, Tomoyoshi Soga

Faculty of Environment and Information Studies

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

Original language	English
Pages (from-to)	11745-11748
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	83
DOIs	https://doi.org/10.1039/c8cc06068a
Publication status	Published - 2018

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection",

abstract = "Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.",

author = "Tatsuya Nishihara and Satoshi Kuno and Hiroshi Nonaka and Sho Tabata and Natsumi Saito and Shinji Fukuda and Masaru Tomita and Shinsuke Sando and Tomoyoshi Soga",

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AU - Nishihara, Tatsuya

AU - Kuno, Satoshi

AU - Nonaka, Hiroshi

AU - Tabata, Sho

AU - Saito, Natsumi

AU - Fukuda, Shinji

AU - Tomita, Masaru

AU - Sando, Shinsuke

AU - Soga, Tomoyoshi

PY - 2018

Y1 - 2018

N2 - Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

AB - Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

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