Abstract
Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.
| Original language | English |
|---|---|
| Pages (from-to) | 11745-11748 |
| Number of pages | 4 |
| Journal | Chemical Communications |
| Volume | 54 |
| Issue number | 83 |
| DOIs | |
| Publication status | Published - 2018 Jan 1 |
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ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Cite this
Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection. / Nishihara, Tatsuya; Kuno, Satoshi; Nonaka, Hiroshi; Tabata, Sho; Saito, Natsumi; Fukuda, Shinji; Tomita, Masaru; Sando, Shinsuke; Soga, Tomoyoshi.
In: Chemical Communications, Vol. 54, No. 83, 01.01.2018, p. 11745-11748.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection
AU - Nishihara, Tatsuya
AU - Kuno, Satoshi
AU - Nonaka, Hiroshi
AU - Tabata, Sho
AU - Saito, Natsumi
AU - Fukuda, Shinji
AU - Tomita, Masaru
AU - Sando, Shinsuke
AU - Soga, Tomoyoshi
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.
AB - Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.
UR - http://www.scopus.com/inward/record.url?scp=85054890632&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054890632&partnerID=8YFLogxK
U2 - 10.1039/c8cc06068a
DO - 10.1039/c8cc06068a
M3 - Article
VL - 54
SP - 11745
EP - 11748
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 83
ER -