Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection

Tatsuya Nishihara, Satoshi Kuno, Hiroshi Nonaka, Sho Tabata, Natsumi Saito, Shinji Fukuda, Masaru Tomita, Shinsuke Sando, Tomoyoshi Soga

Research output: Contribution to journalArticle

Abstract

Tumor biomarkers are highly desirable for the screening of patients with a risk of tumor development and progression. Here, we report a beta-galactosidase (β-gal)-responsive acetaminophen (β-GR-APAP) as a synthetic plasma biomarker for targeted tumor detection. Tumor β-gal labeling via the recognition of tumor-related antigen enabled the detection of a tumor using β-GR-APAP.

Original languageEnglish
Pages (from-to)11745-11748
Number of pages4
JournalChemical Communications
Volume54
Issue number83
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Biomarkers
beta-Galactosidase
Tumors
Acetaminophen
Antigens
Tumor Biomarkers
Labeling
Screening
Galactosidases
Plasmas

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Nishihara, T., Kuno, S., Nonaka, H., Tabata, S., Saito, N., Fukuda, S., ... Soga, T. (2018). Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection. Chemical Communications, 54(83), 11745-11748. https://doi.org/10.1039/c8cc06068a

Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection. / Nishihara, Tatsuya; Kuno, Satoshi; Nonaka, Hiroshi; Tabata, Sho; Saito, Natsumi; Fukuda, Shinji; Tomita, Masaru; Sando, Shinsuke; Soga, Tomoyoshi.

In: Chemical Communications, Vol. 54, No. 83, 01.01.2018, p. 11745-11748.

Research output: Contribution to journalArticle

Nishihara, T, Kuno, S, Nonaka, H, Tabata, S, Saito, N, Fukuda, S, Tomita, M, Sando, S & Soga, T 2018, 'Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection', Chemical Communications, vol. 54, no. 83, pp. 11745-11748. https://doi.org/10.1039/c8cc06068a
Nishihara T, Kuno S, Nonaka H, Tabata S, Saito N, Fukuda S et al. Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection. Chemical Communications. 2018 Jan 1;54(83):11745-11748. https://doi.org/10.1039/c8cc06068a
Nishihara, Tatsuya ; Kuno, Satoshi ; Nonaka, Hiroshi ; Tabata, Sho ; Saito, Natsumi ; Fukuda, Shinji ; Tomita, Masaru ; Sando, Shinsuke ; Soga, Tomoyoshi. / Beta-galactosidase-responsive synthetic biomarker for targeted tumor detection. In: Chemical Communications. 2018 ; Vol. 54, No. 83. pp. 11745-11748.
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