Bilateral coherence between motor cortices and subthalamic nuclei in patients with Parkinson's disease

Kenji Kato, Fusako Yokochi, Makoto Taniguchi, Ryoichi Okiyama, Takashi Kawasaki, Katsuo Kimura, Junichi Ushiba

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: It has been suggested that abnormal synchronization and oscillation of neuronal activity in the subthalamic nucleus (STN) is associated with sensorimotor dysfunction in Parkinson's disease (PD). We investigated the bilateral subcortico-cortical functional coupling in PD patients. Methods: We simultaneously recorded local field potentials from the bilateral STN using electrodes inserted for deep brain stimulation and electroencephalograms from the bilateral motor cortices (MCx) in 11 patients at rest, and analyzed their coherences and causalities. Results: Significant coherence in the sub-beta and beta frequency bands was simultaneously observed between the STN and contralateral STN (STN-cSTN), the STN and ipsilateral MCx (STN-iMCx), and the STN and contralateral MCx (STN-cMCx). In each patient, the frequency of the peak STN-cSTN coherence was similar to that of the peak STN-iMCx and STN-cMCx coherence. The causality between the STN and MCx was strongest in the one-way direction from the MCx to the ipsilateral STN. Conclusions: Abnormal oscillations in the STN in the sub-beta and beta bands were functionally coupled among bilateral STN and MCx at the eigen-frequency in individual patients with PD. Significance: Synchronized activity through cortico-subcortical transmission may have an important role in the pathophysiology of PD.

Original languageEnglish
Pages (from-to)1941-1950
Number of pages10
JournalClinical Neurophysiology
Volume126
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

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Keywords

  • Coherence
  • Deep brain stimulation
  • Motor cortex
  • Neuronal oscillations
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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