Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma

Toshiya Kuno, Takashi Fukutomi, Sadako Akashi-Tanaka, Takeshi Nanasawa, Yae Kanai, Hitoshi Tsuda, Tadashi Nomizu, Yoshio Miki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 34-year-old premenopausal woman developed asynchronous bilateral nonpalpable breast cancers at the age of 32 and 34 years. She had undergone amputation of her left lower leg because of osteosarcoma at the age of 16. Her mother had been diagnosed with breast cancer at the age of 45. The clinicopathological features of the two breast tumors in this patient closely resembled each other; both were nonpalpable, and detectable only by helical CT scan. Histologically, they consisted mainly of an intraductal component with small grade 3 invasive foci. In addition, both tumors estrogen receptor (ER) status was negative, and both were positive for c-erbB-2 protein on immunohistochemical staining. A missense germ line mutation of BRCA2 (exon 25 codon 3118; Met31 1 8Thr) was detected in this patient. These data may provide useful information on the carcinogenesis and biological behavior of breast cancers which develop in patients with BRCA2 germ line mutations.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalBreast Cancer
Volume6
Issue number1
DOIs
Publication statusPublished - 1999 Jan
Externally publishedYes

Keywords

  • BRCA2
  • Hereditary breast cancer
  • Histological grade
  • Osteosarcoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

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    Kuno, T., Fukutomi, T., Akashi-Tanaka, S., Nanasawa, T., Kanai, Y., Tsuda, H., Nomizu, T., & Miki, Y. (1999). Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma. Breast Cancer, 6(1), 51-54. https://doi.org/10.1007/BF02966906