Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma

Toshiya Kuno, Takashi Fukutomi, Sadako Akashi-Tanaka, Takeshi Nanasawa, Yae Kanai, Hitoshi Tsuda, Tadashi Nomizu, Yoshio Miki

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 34-year-old premenopausal woman developed asynchronous bilateral nonpalpable breast cancers at the age of 32 and 34 years. She had undergone amputation of her left lower leg because of osteosarcoma at the age of 16. Her mother had been diagnosed with breast cancer at the age of 45. The clinicopathological features of the two breast tumors in this patient closely resembled each other; both were nonpalpable, and detectable only by helical CT scan. Histologically, they consisted mainly of an intraductal component with small grade 3 invasive foci. In addition, both tumors estrogen receptor (ER) status was negative, and both were positive for c-erbB-2 protein on immunohistochemical staining. A missense germ line mutation of BRCA2 (exon 25 codon 3118; Met31 1 8Thr) was detected in this patient. These data may provide useful information on the carcinogenesis and biological behavior of breast cancers which develop in patients with BRCA2 germ line mutations.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalBreast Cancer
Volume6
Issue number1
DOIs
Publication statusPublished - 1999 Jan
Externally publishedYes

Fingerprint

Germ-Line Mutation
Osteosarcoma
Breast Neoplasms
ErbB-2 Receptor
Spiral Computed Tomography
Missense Mutation
Amputation
Codon
Estrogen Receptors
Exons
Leg
Carcinogenesis
Mothers
Staining and Labeling
Neoplasms

Keywords

  • BRCA2
  • Hereditary breast cancer
  • Histological grade
  • Osteosarcoma

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

Cite this

Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma. / Kuno, Toshiya; Fukutomi, Takashi; Akashi-Tanaka, Sadako; Nanasawa, Takeshi; Kanai, Yae; Tsuda, Hitoshi; Nomizu, Tadashi; Miki, Yoshio.

In: Breast Cancer, Vol. 6, No. 1, 01.1999, p. 51-54.

Research output: Contribution to journalArticle

Kuno, T, Fukutomi, T, Akashi-Tanaka, S, Nanasawa, T, Kanai, Y, Tsuda, H, Nomizu, T & Miki, Y 1999, 'Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma', Breast Cancer, vol. 6, no. 1, pp. 51-54. https://doi.org/10.1007/BF02966906
Kuno, Toshiya ; Fukutomi, Takashi ; Akashi-Tanaka, Sadako ; Nanasawa, Takeshi ; Kanai, Yae ; Tsuda, Hitoshi ; Nomizu, Tadashi ; Miki, Yoshio. / Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma. In: Breast Cancer. 1999 ; Vol. 6, No. 1. pp. 51-54.
@article{c0855547e366447a8d77996ee78115ac,
title = "Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma",
abstract = "A 34-year-old premenopausal woman developed asynchronous bilateral nonpalpable breast cancers at the age of 32 and 34 years. She had undergone amputation of her left lower leg because of osteosarcoma at the age of 16. Her mother had been diagnosed with breast cancer at the age of 45. The clinicopathological features of the two breast tumors in this patient closely resembled each other; both were nonpalpable, and detectable only by helical CT scan. Histologically, they consisted mainly of an intraductal component with small grade 3 invasive foci. In addition, both tumors estrogen receptor (ER) status was negative, and both were positive for c-erbB-2 protein on immunohistochemical staining. A missense germ line mutation of BRCA2 (exon 25 codon 3118; Met31 1 8Thr) was detected in this patient. These data may provide useful information on the carcinogenesis and biological behavior of breast cancers which develop in patients with BRCA2 germ line mutations.",
keywords = "BRCA2, Hereditary breast cancer, Histological grade, Osteosarcoma",
author = "Toshiya Kuno and Takashi Fukutomi and Sadako Akashi-Tanaka and Takeshi Nanasawa and Yae Kanai and Hitoshi Tsuda and Tadashi Nomizu and Yoshio Miki",
year = "1999",
month = "1",
doi = "10.1007/BF02966906",
language = "English",
volume = "6",
pages = "51--54",
journal = "Breast Cancer",
issn = "1340-6868",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - Bilateral nonpalpable breast carcinomas in a patient with BRCA2 germ line mutation and past history of osteosarcoma

AU - Kuno, Toshiya

AU - Fukutomi, Takashi

AU - Akashi-Tanaka, Sadako

AU - Nanasawa, Takeshi

AU - Kanai, Yae

AU - Tsuda, Hitoshi

AU - Nomizu, Tadashi

AU - Miki, Yoshio

PY - 1999/1

Y1 - 1999/1

N2 - A 34-year-old premenopausal woman developed asynchronous bilateral nonpalpable breast cancers at the age of 32 and 34 years. She had undergone amputation of her left lower leg because of osteosarcoma at the age of 16. Her mother had been diagnosed with breast cancer at the age of 45. The clinicopathological features of the two breast tumors in this patient closely resembled each other; both were nonpalpable, and detectable only by helical CT scan. Histologically, they consisted mainly of an intraductal component with small grade 3 invasive foci. In addition, both tumors estrogen receptor (ER) status was negative, and both were positive for c-erbB-2 protein on immunohistochemical staining. A missense germ line mutation of BRCA2 (exon 25 codon 3118; Met31 1 8Thr) was detected in this patient. These data may provide useful information on the carcinogenesis and biological behavior of breast cancers which develop in patients with BRCA2 germ line mutations.

AB - A 34-year-old premenopausal woman developed asynchronous bilateral nonpalpable breast cancers at the age of 32 and 34 years. She had undergone amputation of her left lower leg because of osteosarcoma at the age of 16. Her mother had been diagnosed with breast cancer at the age of 45. The clinicopathological features of the two breast tumors in this patient closely resembled each other; both were nonpalpable, and detectable only by helical CT scan. Histologically, they consisted mainly of an intraductal component with small grade 3 invasive foci. In addition, both tumors estrogen receptor (ER) status was negative, and both were positive for c-erbB-2 protein on immunohistochemical staining. A missense germ line mutation of BRCA2 (exon 25 codon 3118; Met31 1 8Thr) was detected in this patient. These data may provide useful information on the carcinogenesis and biological behavior of breast cancers which develop in patients with BRCA2 germ line mutations.

KW - BRCA2

KW - Hereditary breast cancer

KW - Histological grade

KW - Osteosarcoma

UR - http://www.scopus.com/inward/record.url?scp=1842626854&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842626854&partnerID=8YFLogxK

U2 - 10.1007/BF02966906

DO - 10.1007/BF02966906

M3 - Article

AN - SCOPUS:1842626854

VL - 6

SP - 51

EP - 54

JO - Breast Cancer

JF - Breast Cancer

SN - 1340-6868

IS - 1

ER -