Bilberry extract supplementation for preventing eye fatigue in video display terminal workers

Yoko Ozawa, M. Kawashima, S. Inoue, E. Inagaki, A. Suzuki, E. Ooe, S. Kobayashi, Kazuo Tsubota

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objectives: To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads.Design and setting: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan.Participants: Two hundred eighty-one office workers aged 20–40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA).Intervention: The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks.Measurements: The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo.Results: Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10–1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group.Conclusions: BE supplementation improved some of the objective and subjective parameters of eye fatigue induced by VDT loads.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalJournal of Nutrition, Health and Aging
Volume19
Issue number5
DOIs
Publication statusPublished - 2015 May 1

Fingerprint

Vaccinium myrtillus
Computer Terminals
Asthenopia
Flicker Fusion
Placebos
Visual Acuity
Eye Pain
Dietary Supplements
Dermatology
Foreign Bodies
Fluorescein
Tears
Capsules
Orthopedics
Japan
Confidence Intervals
Interviews
Control Groups

Keywords

  • anthocyanins
  • bilberry extract
  • Eye fatigue
  • video display terminal

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

Bilberry extract supplementation for preventing eye fatigue in video display terminal workers. / Ozawa, Yoko; Kawashima, M.; Inoue, S.; Inagaki, E.; Suzuki, A.; Ooe, E.; Kobayashi, S.; Tsubota, Kazuo.

In: Journal of Nutrition, Health and Aging, Vol. 19, No. 5, 01.05.2015, p. 548-554.

Research output: Contribution to journalArticle

Ozawa, Yoko ; Kawashima, M. ; Inoue, S. ; Inagaki, E. ; Suzuki, A. ; Ooe, E. ; Kobayashi, S. ; Tsubota, Kazuo. / Bilberry extract supplementation for preventing eye fatigue in video display terminal workers. In: Journal of Nutrition, Health and Aging. 2015 ; Vol. 19, No. 5. pp. 548-554.
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