Bile acids and esophageal cancer

Juntaro Matsuzaki, Hidekazu Suzuki

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


The incidence rates of esophageal adenocarcinoma and its precursor lesion, Barrett's esophagus, have increased considerably in Western countries. Duodenogastroesophageal bile reflux is the major cause of this disease. Bile acids induce cytotoxicity in the esophageal epithelium through production of reactive oxygen species and activation of nuclear factor-kB and its downstream signaling pathways. Recent studies have revealed the characteristics of bile acid receptors and transporters in Barrett's esophagus and esophageal adenocarcinoma.

Original languageEnglish
Title of host publicationBile Acids in Gastroenterology
Subtitle of host publicationBasic and Clinical
PublisherSpringer Japan
Number of pages8
ISBN (Electronic)9784431560623
ISBN (Print)9784431560609
Publication statusPublished - 2017 Apr 3


  • Barrett's esophagus
  • CDX2
  • FXR
  • Oxidative stress
  • TGR5

ASJC Scopus subject areas

  • Medicine(all)


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