Bile acids and esophageal cancer

Juntaro Matsuzaki; Hidekazu Suzuki

doi:10.1007/978-4-431-56062-3_13

Bile acids and esophageal cancer

Juntaro Matsuzaki, Hidekazu Suzuki

Medical Education Center

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

The incidence rates of esophageal adenocarcinoma and its precursor lesion, Barrett's esophagus, have increased considerably in Western countries. Duodenogastroesophageal bile reflux is the major cause of this disease. Bile acids induce cytotoxicity in the esophageal epithelium through production of reactive oxygen species and activation of nuclear factor-kB and its downstream signaling pathways. Recent studies have revealed the characteristics of bile acid receptors and transporters in Barrett's esophagus and esophageal adenocarcinoma.

Original language	English
Title of host publication	Bile Acids in Gastroenterology
Subtitle of host publication	Basic and Clinical
Publisher	Springer Japan
Pages	177-184
Number of pages	8
ISBN (Electronic)	9784431560623
ISBN (Print)	9784431560609
DOIs	https://doi.org/10.1007/978-4-431-56062-3_13
Publication status	Published - 2017 Apr 3

Keywords

Barrett's esophagus
CDX2
FXR
Oxidative stress
TGR5

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-4-431-56062-3_13

Cite this

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AB - The incidence rates of esophageal adenocarcinoma and its precursor lesion, Barrett's esophagus, have increased considerably in Western countries. Duodenogastroesophageal bile reflux is the major cause of this disease. Bile acids induce cytotoxicity in the esophageal epithelium through production of reactive oxygen species and activation of nuclear factor-kB and its downstream signaling pathways. Recent studies have revealed the characteristics of bile acid receptors and transporters in Barrett's esophagus and esophageal adenocarcinoma.

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KW - CDX2

KW - FXR

KW - Oxidative stress

KW - TGR5

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PB - Springer Japan

ER -

Bile acids and esophageal cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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