Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2

Daryono H. Tjahjono, Suhendar, Benny Permana, Naoki Yoshioka, Hidenari Inoue

Research output: Contribution to journalArticle

Abstract

The interaction of nickel(II) complex of cationic porphyrins bearing five-membered rings, meso-tetrakis(1,2-dimethylpyrazolium-4-yl) porphyrinatonickel(II) (NiPzP), with synthetic polynucleotides poly(dG-dC) 2 and poly(dA-dT) 2 has been characterized by viscometric, visible absorption, CD and MCD spectroscopic, and melting temperature measurements. The nickel(II) complex NiPzP is intercalated into poly(dG-dC) 2 but outside bound to the major groove of poly(dA-dT) 2. The binding constants of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 are in the order of 10 6 M -1 and comparable to those of other reported cationic metalloporphyrins. The binding process of NiPzP to poly(dG-dC) 2 and poly(dA-dT) 2 is endothermic and entropically driven.

Original languageEnglish
Pages (from-to)305-313
Number of pages9
JournalJournal of Porphyrins and Phthalocyanines
Volume14
Issue number4
DOIs
Publication statusPublished - 2010 Apr

Fingerprint

Poly dA-dT
Porphyrins
Nickel
Bearings (structural)
Metalloporphyrins
Polynucleotides
Temperature measurement
Melting point
poly(dC-dG)

Keywords

  • Metallopyrazolium-4-ylporphyrin
  • Poly(dA-dT)
  • Poly(dG-dC)
  • Porphyrin-DNA interaction
  • Thermodynamic parameters

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2. / Tjahjono, Daryono H.; Suhendar; Permana, Benny; Yoshioka, Naoki; Inoue, Hidenari.

In: Journal of Porphyrins and Phthalocyanines, Vol. 14, No. 4, 04.2010, p. 305-313.

Research output: Contribution to journalArticle

Tjahjono, Daryono H. ; Suhendar ; Permana, Benny ; Yoshioka, Naoki ; Inoue, Hidenari. / Binding of nickel(II) tetrakis(dimethylpyrazolium-4-yl) porphyrin to poly(dG-dC) 2 and poly(dA-dT) 2. In: Journal of Porphyrins and Phthalocyanines. 2010 ; Vol. 14, No. 4. pp. 305-313.
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