Bioactive secondary metabolites from symbiotic marine dinoflagellates: Symbiodinolide and durinskiols

Masaki Kita, Osamu Ohno, Chunguang Han, Daisuke Uemura

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Symbiotic relationships play critical roles in marine ecosystems. Among symbionts, marine dinoflagellates have attracted the attention of natural products chemists, biologists, and ecologists, since they are rich sources of unique bioactive secondary metabolites. The polyol compound symbiodinolide, which was isolated from the symbiotic dinoflagellate Symbiodinium sp., exhibits significant voltage-dependent N-type Ca2+ channel-opening activity and may serve as a defense substance to prevent digestion of the host animals. Durinskiols are also unique long carbon-chain polyol compounds that were isolated from the dinoflagellate Durinskia sp. We found a selective cleavage reaction of allylic 1,2-diol using an olefin metathesis catalyst, and developed a fluorescent-labeling method for MS/MS analysis to achieve the structural elucidation of huge polyol compounds. This review highlights recent advances in structural and biological studies on symbiodinolide, durinskiols, and related polyol compounds.

Original languageEnglish
Pages (from-to)57-69
Number of pages13
JournalChemical Record
Volume10
Issue number2
DOIs
Publication statusPublished - 2010 Apr

Fingerprint

Dinoflagellida
Polyols
Metabolites
Aquatic ecosystems
Alkenes
Biological Products
Labeling
Olefins
Ecosystem
Digestion
Animals
Carbon
Catalysts
symbiodinolide
polyol
Electric potential

Keywords

  • Chemical ecology
  • Long carbon-chain polyol compounds
  • Marine natural products
  • Symbiosis

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry
  • Biochemistry
  • Biochemistry, medical

Cite this

Bioactive secondary metabolites from symbiotic marine dinoflagellates : Symbiodinolide and durinskiols. / Kita, Masaki; Ohno, Osamu; Han, Chunguang; Uemura, Daisuke.

In: Chemical Record, Vol. 10, No. 2, 04.2010, p. 57-69.

Research output: Contribution to journalArticle

Kita, Masaki ; Ohno, Osamu ; Han, Chunguang ; Uemura, Daisuke. / Bioactive secondary metabolites from symbiotic marine dinoflagellates : Symbiodinolide and durinskiols. In: Chemical Record. 2010 ; Vol. 10, No. 2. pp. 57-69.
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