Bioactive secondary metabolites with unique aromatic and heterocyclic structures obtained from terrestrial actinomycetes species

Mohamed S. Abdelfattah, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Natural products from actinomycetes are important and valuable sources for drug discovery and the development of biological tools. The present review describes our recent study on the isolation of new naturalproducts mainly possessing heterocyclic and aromatic ring structures with biological effects on cancer-relatedcellular pathways such as tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) and Wnt signaling.

Original languageEnglish
Pages (from-to)668-675
Number of pages8
JournalChemical and Pharmaceutical Bulletin
Volume64
Issue number7
DOIs
Publication statusPublished - 2016

Keywords

  • Acridine
  • Actinomycete
  • Isobenzofuran
  • Naphthoquinone
  • Phenazine
  • Signaling pathway

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

Fingerprint Dive into the research topics of 'Bioactive secondary metabolites with unique aromatic and heterocyclic structures obtained from terrestrial actinomycetes species'. Together they form a unique fingerprint.

Cite this