Bioassay-guided isolation of compounds from Datura stramonium with TRAIL-resistance overcoming activity

Utpal K. Karmakar, Kazufumi Toume, Naoki Ishikawa, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

TRAIL is a potent inducer of apoptosis in most cancer cells, but not in normal cells, and therefore has deserved intense interest as a promising agent for cancer therapy. In the search for bioactive natural products for overcoming TRAIL-resistance, we previously reported a number of active compounds. In our screening program on natural resources targeting overcoming TRAIL-resistance, activity-guided fractionation of the MeOH extract of Datura stramonium leaves led to the isolation of three alkaloids - scopolamine (1), trigonelline (2), and tyramine (3). Compounds 1, 2, and 3 exhibited TRAIL-resistance overcoming activity at 50, 150, and 100 μM, respectively in TRAIL-resistant AGS cells.

Original languageEnglish
Pages (from-to)185-187
Number of pages3
JournalNatural product communications
Volume11
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Alkaloids
  • Datura stramonium
  • Solanaceae
  • TRAIL-resistance

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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