Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

Takeshi Sugai; Keiji Hamada; Tomohiro Akeboshi; Hajime Ikeda; Hiromichi Ohta

doi:10.1055/s-1997-972

Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

Takeshi Sugai, Keiji Hamada, Tomohiro Akeboshi, Hajime Ikeda, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subseqent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.

Original language	English
Pages (from-to)	983-985
Number of pages	3
Journal	Synlett
Volume	1997
Issue number	8
DOIs	https://doi.org/10.1055/s-1997-972
Publication status	Published - 1997 Jan 1

ASJC Scopus subject areas

Organic Chemistry

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abstract = "Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subseqent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.",

author = "Takeshi Sugai and Keiji Hamada and Tomohiro Akeboshi and Hajime Ikeda and Hiromichi Ohta",

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T1 - Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

AU - Sugai, Takeshi

AU - Hamada, Keiji

AU - Akeboshi, Tomohiro

AU - Ikeda, Hajime

AU - Ohta, Hiromichi

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subseqent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.

AB - Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subseqent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.

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DO - 10.1055/s-1997-972

M3 - Article

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SN - 0936-5214

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JO - Synlett

JF - Synlett

IS - 8

ER -

Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

Abstract

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