Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

Takeshi Sugai, Keiji Hamada, Tomohiro Akeboshi, Hajime Ikeda, Hiromichi Ohta

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Abstract

Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subseqent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.

Original languageEnglish
Pages (from-to)983-985
Number of pages3
JournalSynlett
Volume1997
Issue number8
DOIs
Publication statusPublished - 1997 Jan 1

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ASJC Scopus subject areas

  • Organic Chemistry

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