Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

Takeshi Sugai, Keiji Hamada, Tomohiro Akeboshi, Hajime Ikeda, Hiromichi Ohta

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subseqent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.

Original languageEnglish
Pages (from-to)983-985
Number of pages3
JournalSynlett
Volume1997
Issue number8
Publication statusPublished - 1997

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Lipase
Kinetics
Acids
Enzymes

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Sugai, T., Hamada, K., Akeboshi, T., Ikeda, H., & Ohta, H. (1997). Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide. Synlett, 1997(8), 983-985.

Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide. / Sugai, Takeshi; Hamada, Keiji; Akeboshi, Tomohiro; Ikeda, Hajime; Ohta, Hiromichi.

In: Synlett, Vol. 1997, No. 8, 1997, p. 983-985.

Research output: Contribution to journalArticle

Sugai, T, Hamada, K, Akeboshi, T, Ikeda, H & Ohta, H 1997, 'Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide', Synlett, vol. 1997, no. 8, pp. 983-985.
Sugai, Takeshi ; Hamada, Keiji ; Akeboshi, Tomohiro ; Ikeda, Hajime ; Ohta, Hiromichi. / Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide. In: Synlett. 1997 ; Vol. 1997, No. 8. pp. 983-985.
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