Abstract
In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 51-56 |
| Number of pages | 6 |
| Journal | Bioorganic Chemistry |
| Volume | 57 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Cytotoxic activity
- Liliaceae
- Scilla persica
- Scillapersicone
- Single-crystal X-ray
- Theoretical analysis
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
Cite this
Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN. / Hafez Ghoran, Salar; Saeidnia, Soodabeh; Babaei, Esmaeil; Kiuchi, Fumiyuki; Dusek, Michal; Eigner, Vaclav; Dehno Khalaji, Aliakbar; Soltani, Alireza.
In: Bioorganic Chemistry, Vol. 57, 2014, p. 51-56.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN
AU - Hafez Ghoran, Salar
AU - Saeidnia, Soodabeh
AU - Babaei, Esmaeil
AU - Kiuchi, Fumiyuki
AU - Dusek, Michal
AU - Eigner, Vaclav
AU - Dehno Khalaji, Aliakbar
AU - Soltani, Alireza
PY - 2014
Y1 - 2014
N2 - In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
AB - In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
KW - Cytotoxic activity
KW - Liliaceae
KW - Scilla persica
KW - Scillapersicone
KW - Single-crystal X-ray
KW - Theoretical analysis
UR - http://www.scopus.com/inward/record.url?scp=84906861020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906861020&partnerID=8YFLogxK
U2 - 10.1016/j.bioorg.2014.08.001
DO - 10.1016/j.bioorg.2014.08.001
M3 - Article
C2 - 25181677
AN - SCOPUS:84906861020
VL - 57
SP - 51
EP - 56
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
SN - 0045-2068
ER -