Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Salar Hafez Ghoran, Soodabeh Saeidnia, Esmaeil Babaei, Fumiyuki Kiuchi, Michal Dusek, Vaclav Eigner, Aliakbar Dehno Khalaji, Alireza Soltani

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4 Citations (Scopus)

Abstract

In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalBioorganic Chemistry
Volume57
DOIs
Publication statusPublished - 2014 Dec

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Keywords

  • Cytotoxic activity
  • Liliaceae
  • Scilla persica
  • Scillapersicone
  • Single-crystal X-ray
  • Theoretical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

Cite this

Hafez Ghoran, S., Saeidnia, S., Babaei, E., Kiuchi, F., Dusek, M., Eigner, V., Dehno Khalaji, A., & Soltani, A. (2014). Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN. Bioorganic Chemistry, 57, 51-56. https://doi.org/10.1016/j.bioorg.2014.08.001