Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Salar Hafez Ghoran; Soodabeh Saeidnia; Esmaeil Babaei; Fumiyuki Kiuchi; Michal Dusek; Vaclav Eigner; Aliakbar Dehno Khalaji; Alireza Soltani

doi:10.1016/j.bioorg.2014.08.001

Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Salar Hafez Ghoran, Soodabeh Saeidnia, Esmaeil Babaei, Fumiyuki Kiuchi, Michal Dusek, Vaclav Eigner, Aliakbar Dehno Khalaji, Alireza Soltani

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å³, monoclinic space group P2₁/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.

Original language	English
Pages (from-to)	51-56
Number of pages	6
Journal	Bioorganic Chemistry
Volume	57
DOIs	https://doi.org/10.1016/j.bioorg.2014.08.001
Publication status	Published - 2014 Dec

Keywords

Cytotoxic activity
Liliaceae
Scilla persica
Scillapersicone
Single-crystal X-ray
Theoretical analysis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN. / Hafez Ghoran, Salar; Saeidnia, Soodabeh; Babaei, Esmaeil; Kiuchi, Fumiyuki; Dusek, Michal; Eigner, Vaclav; Dehno Khalaji, Aliakbar; Soltani, Alireza.

In: Bioorganic Chemistry, Vol. 57, 12.2014, p. 51-56.

Research output: Contribution to journal › Article › peer-review

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title = "Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN",

abstract = "In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) {\AA}, b = 20.1174 (4) {\AA}, c = 7.8645 (9) {\AA}, β = 93.544 (2)°, V = 1858.23 (7) {\AA}3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.",

keywords = "Cytotoxic activity, Liliaceae, Scilla persica, Scillapersicone, Single-crystal X-ray, Theoretical analysis",

author = "{Hafez Ghoran}, Salar and Soodabeh Saeidnia and Esmaeil Babaei and Fumiyuki Kiuchi and Michal Dusek and Vaclav Eigner and {Dehno Khalaji}, Aliakbar and Alireza Soltani",

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AU - Hafez Ghoran, Salar

AU - Saeidnia, Soodabeh

AU - Babaei, Esmaeil

AU - Kiuchi, Fumiyuki

AU - Dusek, Michal

AU - Eigner, Vaclav

AU - Dehno Khalaji, Aliakbar

AU - Soltani, Alireza

PY - 2014/12

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N2 - In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.

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KW - Theoretical analysis

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