Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN

Salar Hafez Ghoran, Soodabeh Saeidnia, Esmaeil Babaei, Fumiyuki Kiuchi, Michal Dusek, Vaclav Eigner, Aliakbar Dehno Khalaji, Alireza Soltani

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.

Original languageEnglish
Pages (from-to)51-56
Number of pages6
JournalBioorganic Chemistry
Volume57
DOIs
Publication statusPublished - 2014

Fingerprint

Scilla
Single crystals
X ray crystallography
X Ray Crystallography
X ray analysis
Cytotoxicity
Assays
Cells
Nuclear magnetic resonance
X-Rays
Cell Line
Molecules
Geometry

Keywords

  • Cytotoxic activity
  • Liliaceae
  • Scilla persica
  • Scillapersicone
  • Single-crystal X-ray
  • Theoretical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

Cite this

Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN. / Hafez Ghoran, Salar; Saeidnia, Soodabeh; Babaei, Esmaeil; Kiuchi, Fumiyuki; Dusek, Michal; Eigner, Vaclav; Dehno Khalaji, Aliakbar; Soltani, Alireza.

In: Bioorganic Chemistry, Vol. 57, 2014, p. 51-56.

Research output: Contribution to journalArticle

Hafez Ghoran, S, Saeidnia, S, Babaei, E, Kiuchi, F, Dusek, M, Eigner, V, Dehno Khalaji, A & Soltani, A 2014, 'Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN', Bioorganic Chemistry, vol. 57, pp. 51-56. https://doi.org/10.1016/j.bioorg.2014.08.001
Hafez Ghoran, Salar ; Saeidnia, Soodabeh ; Babaei, Esmaeil ; Kiuchi, Fumiyuki ; Dusek, Michal ; Eigner, Vaclav ; Dehno Khalaji, Aliakbar ; Soltani, Alireza. / Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN. In: Bioorganic Chemistry. 2014 ; Vol. 57. pp. 51-56.
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AU - Kiuchi, Fumiyuki

AU - Dusek, Michal

AU - Eigner, Vaclav

AU - Dehno Khalaji, Aliakbar

AU - Soltani, Alireza

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