TY - JOUR
T1 - Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN
AU - Hafez Ghoran, Salar
AU - Saeidnia, Soodabeh
AU - Babaei, Esmaeil
AU - Kiuchi, Fumiyuki
AU - Dusek, Michal
AU - Eigner, Vaclav
AU - Dehno Khalaji, Aliakbar
AU - Soltani, Alireza
N1 - Funding Information:
The authors wish to thank Mr. Abbas Biglari (Zanjan Institute of Chemistry for NMR spectroscopic measurements, and Dr. Ahmad Reza Gohari and other MPRC colleagues (Medicinal Plants Research Center, Tehran University of Medical Sciences) for their support in isolation and purification process. The authors are also grateful to Golestan University and Tabriz University Research Councils for partial support of this work and the project (14-03276S) of the Grant Agency of the Czech Republic.
PY - 2014/12
Y1 - 2014/12
N2 - In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
AB - In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3′,4′-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a = 11.7676 (2) Å, b = 20.1174 (4) Å, c = 7.8645 (9) Å, β = 93.544 (2)°, V = 1858.23 (7) Å3, monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
KW - Cytotoxic activity
KW - Liliaceae
KW - Scilla persica
KW - Scillapersicone
KW - Single-crystal X-ray
KW - Theoretical analysis
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U2 - 10.1016/j.bioorg.2014.08.001
DO - 10.1016/j.bioorg.2014.08.001
M3 - Article
C2 - 25181677
AN - SCOPUS:84906861020
VL - 57
SP - 51
EP - 56
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
SN - 0045-2068
ER -
