Biochemistry and metabolism of toxoplasma gondii

T. Asai, S. Tomavo

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Toxoplasma gondii and all other parasites of the phylum Apicomplexa reside and replicate exclusively within eukaryotic cells. It suggests that these parasites depend on the metabolism of their hosts and that they have evolved metabolic pathways reflecting their intracellular lifestyle. In addition, these parasites may display specific or alternate metabolism as documented by the recent discovery of novel metabolic pathways in the remnant and vestigial plastid (apicoplast) found in many apicomplexan parasites. While targeting unique parasite pathways is an attractive strategy, in practice the procurement of enough pure parasites for biochemical study or purification of parasite components such as enzymes is extremely difficult. Biochemical and metabolic studies of T. gondii have also been difficult to execute because of continual problems with contamination of parasite preparations with host-cell components. © 2007

Original languageEnglish
Title of host publicationToxoplasma Gondii
PublisherElsevier Ltd
Pages185-206
Number of pages22
ISBN (Print)9780123695420
DOIs
Publication statusPublished - 2007

Fingerprint

Toxoplasma
Toxoplasma gondii
Biochemistry
biochemistry
Parasites
parasites
metabolism
Metabolic Networks and Pathways
biochemical pathways
Apicoplasts
apicoplasts
Apicomplexa
Plastids
metabolic studies
Eukaryotic Cells
Cellular Structures
lifestyle
plastids
eukaryotic cells
Life Style

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Asai, T., & Tomavo, S. (2007). Biochemistry and metabolism of toxoplasma gondii. In Toxoplasma Gondii (pp. 185-206). Elsevier Ltd. https://doi.org/10.1016/B978-012369542-0/50010-6

Biochemistry and metabolism of toxoplasma gondii. / Asai, T.; Tomavo, S.

Toxoplasma Gondii. Elsevier Ltd, 2007. p. 185-206.

Research output: Chapter in Book/Report/Conference proceedingChapter

Asai, T & Tomavo, S 2007, Biochemistry and metabolism of toxoplasma gondii. in Toxoplasma Gondii. Elsevier Ltd, pp. 185-206. https://doi.org/10.1016/B978-012369542-0/50010-6
Asai T, Tomavo S. Biochemistry and metabolism of toxoplasma gondii. In Toxoplasma Gondii. Elsevier Ltd. 2007. p. 185-206 https://doi.org/10.1016/B978-012369542-0/50010-6
Asai, T. ; Tomavo, S. / Biochemistry and metabolism of toxoplasma gondii. Toxoplasma Gondii. Elsevier Ltd, 2007. pp. 185-206
@inbook{8a85eff3b55548b4af7ad5e4c33e1f91,
title = "Biochemistry and metabolism of toxoplasma gondii",
abstract = "Toxoplasma gondii and all other parasites of the phylum Apicomplexa reside and replicate exclusively within eukaryotic cells. It suggests that these parasites depend on the metabolism of their hosts and that they have evolved metabolic pathways reflecting their intracellular lifestyle. In addition, these parasites may display specific or alternate metabolism as documented by the recent discovery of novel metabolic pathways in the remnant and vestigial plastid (apicoplast) found in many apicomplexan parasites. While targeting unique parasite pathways is an attractive strategy, in practice the procurement of enough pure parasites for biochemical study or purification of parasite components such as enzymes is extremely difficult. Biochemical and metabolic studies of T. gondii have also been difficult to execute because of continual problems with contamination of parasite preparations with host-cell components. {\circledC} 2007",
author = "T. Asai and S. Tomavo",
year = "2007",
doi = "10.1016/B978-012369542-0/50010-6",
language = "English",
isbn = "9780123695420",
pages = "185--206",
booktitle = "Toxoplasma Gondii",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Biochemistry and metabolism of toxoplasma gondii

AU - Asai, T.

AU - Tomavo, S.

PY - 2007

Y1 - 2007

N2 - Toxoplasma gondii and all other parasites of the phylum Apicomplexa reside and replicate exclusively within eukaryotic cells. It suggests that these parasites depend on the metabolism of their hosts and that they have evolved metabolic pathways reflecting their intracellular lifestyle. In addition, these parasites may display specific or alternate metabolism as documented by the recent discovery of novel metabolic pathways in the remnant and vestigial plastid (apicoplast) found in many apicomplexan parasites. While targeting unique parasite pathways is an attractive strategy, in practice the procurement of enough pure parasites for biochemical study or purification of parasite components such as enzymes is extremely difficult. Biochemical and metabolic studies of T. gondii have also been difficult to execute because of continual problems with contamination of parasite preparations with host-cell components. © 2007

AB - Toxoplasma gondii and all other parasites of the phylum Apicomplexa reside and replicate exclusively within eukaryotic cells. It suggests that these parasites depend on the metabolism of their hosts and that they have evolved metabolic pathways reflecting their intracellular lifestyle. In addition, these parasites may display specific or alternate metabolism as documented by the recent discovery of novel metabolic pathways in the remnant and vestigial plastid (apicoplast) found in many apicomplexan parasites. While targeting unique parasite pathways is an attractive strategy, in practice the procurement of enough pure parasites for biochemical study or purification of parasite components such as enzymes is extremely difficult. Biochemical and metabolic studies of T. gondii have also been difficult to execute because of continual problems with contamination of parasite preparations with host-cell components. © 2007

UR - http://www.scopus.com/inward/record.url?scp=82555160642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82555160642&partnerID=8YFLogxK

U2 - 10.1016/B978-012369542-0/50010-6

DO - 10.1016/B978-012369542-0/50010-6

M3 - Chapter

AN - SCOPUS:82555160642

SN - 9780123695420

SP - 185

EP - 206

BT - Toxoplasma Gondii

PB - Elsevier Ltd

ER -