Biochemistry and Metabolism of Toxoplasma gondii. Carbohydrates, Lipids and Nucleotides.

Isabelle Coppens, Takashi Asai, Stanislas Tomavo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

As obligate intracellular parasites, the Apicomplexa, including Toxoplasma gondii, must either synthesize or acquire essential nutrients while evading host defenses. The metabolic pathways of Toxoplasma reflect the evolutionary relationship of the Apicomplexa to plants as illustrated by the activities of the relict plastid, the apicoplast, as well as other plant-like pathways, such as amylopectin synthesis. Carbohydrate metabolism is developmentally regulated in T. gondii with specialized enzymes for different life-cycle stages. More recent studies have revealed that lipid metabolism consists of unique and conserved scavenging and biosynthetic capabilities. This chapter highlights the metabolic pathways of T. gondii and illustrates important and unique aspects of carbohydrate, lipid and nucleotide metabolism that may pose potential drug targets.

Original languageEnglish
Title of host publicationToxoplasma Gondii
Subtitle of host publicationThe Model Apicomplexan - Perspectives and Methods: Second Edition
PublisherElsevier Ltd
Pages257-295
Number of pages39
ISBN (Print)9780123964816
DOIs
Publication statusPublished - 2013 Sep 1

Keywords

  • Amylopectin
  • Glycolipid
  • Isoprenoid
  • Nucleoside triphosphate hydrolase (NTPase)
  • Phospholipid
  • Purine
  • Pyrimidine
  • Sphingolipid

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

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    Coppens, I., Asai, T., & Tomavo, S. (2013). Biochemistry and Metabolism of Toxoplasma gondii. Carbohydrates, Lipids and Nucleotides. In Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods: Second Edition (pp. 257-295). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-396481-6.00008-8