Biocompatibility tests and adhesion improvements for hydrogen-free amorphous carbon for blood-contacting medical devices

Yuya Yamato, Shunto Maegawa, Terumitsu Hasebe, Kenta Bito, Tomohiro Matsumoto, Takahiko Mine, Toshihiko Hayashi, Atsushi Hotta, Tetsuya Suzuki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The hydrogenated amorphous carbon (a-C:H) film has been known as a coating material that imparts improved biocompatibility to base materials and has been used for many clinical applications. Recent studies have revealed that hydrogen-free amorphous carbon (H-free a-C) on stainless steel (SUS) has beneficial antibacterial properties, which allow avoidance of the risk of bacterial infection. In our study, to evaluate the biocompatibility of H-free a-C itself for blood-contacting devices, we investigated not only the ability to grow bacteria but also platelet aggregation on the surfaces of H-free a-C. Moreover, to apply H-free a-C to polytetrafluoroethylene (PTFE), we evaluated the adhesive properties of H-free a-C deposited after Ar or O 2 plasma pre-treatment and fluorine-incorporated a-C:H (a-C:H:F) interlayer deposition. Antibacterial tests and antithrombogenic tests indicated that H-free a-C coating reduced bacterial adhesion and platelet activation in comparison with a-C:H coating. The adhesive strength of plasma-treated Ar and the interlayer deposited PTFE was five times larger than those of untreated PTFE from film adhesion tests. These results indicated that the pre-treated PTFE coated with H-free a-C is a promising candidate biomaterial for medical devices.

Original languageEnglish
Pages (from-to)843-854
Number of pages12
JournalSensors and Materials
Volume29
Issue number6
DOIs
Publication statusPublished - 2017 Jan 1

Fingerprint

polytetrafluoroethylene
Amorphous carbon
Polytetrafluoroethylene
biocompatibility
Biocompatibility
Polytetrafluoroethylenes
blood
Hydrogen
adhesion
Blood
Adhesion
carbon
hydrogen
Platelets
platelets
coatings
Coatings
adhesives
interlayers
Adhesives

Keywords

  • Adhesive properties
  • Amorphous carbon
  • Biocompatibility
  • Biomaterial

ASJC Scopus subject areas

  • Instrumentation
  • Materials Science(all)

Cite this

Biocompatibility tests and adhesion improvements for hydrogen-free amorphous carbon for blood-contacting medical devices. / Yamato, Yuya; Maegawa, Shunto; Hasebe, Terumitsu; Bito, Kenta; Matsumoto, Tomohiro; Mine, Takahiko; Hayashi, Toshihiko; Hotta, Atsushi; Suzuki, Tetsuya.

In: Sensors and Materials, Vol. 29, No. 6, 01.01.2017, p. 843-854.

Research output: Contribution to journalArticle

Yamato, Yuya ; Maegawa, Shunto ; Hasebe, Terumitsu ; Bito, Kenta ; Matsumoto, Tomohiro ; Mine, Takahiko ; Hayashi, Toshihiko ; Hotta, Atsushi ; Suzuki, Tetsuya. / Biocompatibility tests and adhesion improvements for hydrogen-free amorphous carbon for blood-contacting medical devices. In: Sensors and Materials. 2017 ; Vol. 29, No. 6. pp. 843-854.
@article{f13d408d790640d0bc5f84971da04ff9,
title = "Biocompatibility tests and adhesion improvements for hydrogen-free amorphous carbon for blood-contacting medical devices",
abstract = "The hydrogenated amorphous carbon (a-C:H) film has been known as a coating material that imparts improved biocompatibility to base materials and has been used for many clinical applications. Recent studies have revealed that hydrogen-free amorphous carbon (H-free a-C) on stainless steel (SUS) has beneficial antibacterial properties, which allow avoidance of the risk of bacterial infection. In our study, to evaluate the biocompatibility of H-free a-C itself for blood-contacting devices, we investigated not only the ability to grow bacteria but also platelet aggregation on the surfaces of H-free a-C. Moreover, to apply H-free a-C to polytetrafluoroethylene (PTFE), we evaluated the adhesive properties of H-free a-C deposited after Ar or O 2 plasma pre-treatment and fluorine-incorporated a-C:H (a-C:H:F) interlayer deposition. Antibacterial tests and antithrombogenic tests indicated that H-free a-C coating reduced bacterial adhesion and platelet activation in comparison with a-C:H coating. The adhesive strength of plasma-treated Ar and the interlayer deposited PTFE was five times larger than those of untreated PTFE from film adhesion tests. These results indicated that the pre-treated PTFE coated with H-free a-C is a promising candidate biomaterial for medical devices.",
keywords = "Adhesive properties, Amorphous carbon, Biocompatibility, Biomaterial",
author = "Yuya Yamato and Shunto Maegawa and Terumitsu Hasebe and Kenta Bito and Tomohiro Matsumoto and Takahiko Mine and Toshihiko Hayashi and Atsushi Hotta and Tetsuya Suzuki",
year = "2017",
month = "1",
day = "1",
doi = "10.18494/SAM.2017.1573",
language = "English",
volume = "29",
pages = "843--854",
journal = "Sensors and Materials",
issn = "0914-4935",
publisher = "M Y U Scientific Publishing Division",
number = "6",

}

TY - JOUR

T1 - Biocompatibility tests and adhesion improvements for hydrogen-free amorphous carbon for blood-contacting medical devices

AU - Yamato, Yuya

AU - Maegawa, Shunto

AU - Hasebe, Terumitsu

AU - Bito, Kenta

AU - Matsumoto, Tomohiro

AU - Mine, Takahiko

AU - Hayashi, Toshihiko

AU - Hotta, Atsushi

AU - Suzuki, Tetsuya

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The hydrogenated amorphous carbon (a-C:H) film has been known as a coating material that imparts improved biocompatibility to base materials and has been used for many clinical applications. Recent studies have revealed that hydrogen-free amorphous carbon (H-free a-C) on stainless steel (SUS) has beneficial antibacterial properties, which allow avoidance of the risk of bacterial infection. In our study, to evaluate the biocompatibility of H-free a-C itself for blood-contacting devices, we investigated not only the ability to grow bacteria but also platelet aggregation on the surfaces of H-free a-C. Moreover, to apply H-free a-C to polytetrafluoroethylene (PTFE), we evaluated the adhesive properties of H-free a-C deposited after Ar or O 2 plasma pre-treatment and fluorine-incorporated a-C:H (a-C:H:F) interlayer deposition. Antibacterial tests and antithrombogenic tests indicated that H-free a-C coating reduced bacterial adhesion and platelet activation in comparison with a-C:H coating. The adhesive strength of plasma-treated Ar and the interlayer deposited PTFE was five times larger than those of untreated PTFE from film adhesion tests. These results indicated that the pre-treated PTFE coated with H-free a-C is a promising candidate biomaterial for medical devices.

AB - The hydrogenated amorphous carbon (a-C:H) film has been known as a coating material that imparts improved biocompatibility to base materials and has been used for many clinical applications. Recent studies have revealed that hydrogen-free amorphous carbon (H-free a-C) on stainless steel (SUS) has beneficial antibacterial properties, which allow avoidance of the risk of bacterial infection. In our study, to evaluate the biocompatibility of H-free a-C itself for blood-contacting devices, we investigated not only the ability to grow bacteria but also platelet aggregation on the surfaces of H-free a-C. Moreover, to apply H-free a-C to polytetrafluoroethylene (PTFE), we evaluated the adhesive properties of H-free a-C deposited after Ar or O 2 plasma pre-treatment and fluorine-incorporated a-C:H (a-C:H:F) interlayer deposition. Antibacterial tests and antithrombogenic tests indicated that H-free a-C coating reduced bacterial adhesion and platelet activation in comparison with a-C:H coating. The adhesive strength of plasma-treated Ar and the interlayer deposited PTFE was five times larger than those of untreated PTFE from film adhesion tests. These results indicated that the pre-treated PTFE coated with H-free a-C is a promising candidate biomaterial for medical devices.

KW - Adhesive properties

KW - Amorphous carbon

KW - Biocompatibility

KW - Biomaterial

UR - http://www.scopus.com/inward/record.url?scp=85044355369&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044355369&partnerID=8YFLogxK

U2 - 10.18494/SAM.2017.1573

DO - 10.18494/SAM.2017.1573

M3 - Article

AN - SCOPUS:85044355369

VL - 29

SP - 843

EP - 854

JO - Sensors and Materials

JF - Sensors and Materials

SN - 0914-4935

IS - 6

ER -