Biodegradable polycaprolactone nanofibres with β-chitosan and calcium carbonate produce a hemostatic effect

Jun Yong Park, Kyu Hong Kyung, Kosuke Tsukada, Sae Hoon Kim, Seimei Shiratori

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We newly developed high-performance blood coagulation nanofibres using Polycaprolactone (PCL) including Calcium carbonate (CaCO3) and β-chitosan. The most important feature for a wound dressing is that it is harmless to the human body. Here, we fabricated the nanofibre using all human-safe materials. We used a PCL nanofibre mat as a substrate and then synthesized artificial CaCO3 from sodium carbonate and calcium chloride. The CaCO3 was then added to the fibre solution to create PCL/CaCO3 nanofibres. We coated PCL and PCL/CaCO3 nanofibres with β-chitosan as a hemostatic material via a spray method. For the more uniform coating, we used ultrasonic spray coating method and then compared the blood coagulation abilities of the PCL and PCL/CaCO3 nanofibres. We found that the PCL/CaCO3 nanofibres sprayed with β-chitosan had a greater effect on blood coagulation than the PCL nanofibres. In the result of animal experiment, β-chitosan have a key role in changing of surface wettability from hydrophobic to hydrophilic. Moreover, this is contributed to enhance blood coagulability. PCL/CaCO3 nanofibres sprayed with β-chitosan therefore offer promise in medical applications.

Original languageEnglish
Pages (from-to)194-202
Number of pages9
JournalPolymer (United Kingdom)
Volume123
DOIs
Publication statusPublished - 2017 Aug 11

Keywords

  • Calcium carbonate
  • Electrospinning
  • Hemostatic effect
  • Nanofibre
  • Polycaprolactone
  • β-chitosan

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry

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