Biofabrication of pseudocardiac tublar tissues with gel fibers including rat cardiomyocytes

Shintaroh Iwanaga, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes a tissue-fabrication method utilizing with 'cell fiber': a core-shell hydrogel fiber encapsulating cells in the core. We use coaxial microfluidic channels to fabricate collagen/alginate or fibrin/alginate core-shell fibers. Rat primary cardiomyocytes were well cultured within the fibrin-based cell fiber, successfully contracting with the alginate shell. By twisting up cardio-fibers, we can easily prepare coiled tublar tissues. This approach would be applicable for the rapid biofabrication of large-scaled 3D tissues.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages861-863
Number of pages3
Publication statusPublished - 2011 Dec 1
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume2

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Keywords

  • Cardiomyocyte
  • Core-shell fiber
  • Hydrogel
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Iwanaga, S., Onoe, H., & Takeuchi, S. (2011). Biofabrication of pseudocardiac tublar tissues with gel fibers including rat cardiomyocytes. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 861-863). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 2).