Biofabrication of pseudocardiac tublar tissues with gel fibers including rat cardiomyocytes

Shintaroh Iwanaga, Hiroaki Onoe, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes a tissue-fabrication method utilizing with 'cell fiber': a core-shell hydrogel fiber encapsulating cells in the core. We use coaxial microfluidic channels to fabricate collagen/alginate or fibrin/alginate core-shell fibers. Rat primary cardiomyocytes were well cultured within the fibrin-based cell fiber, successfully contracting with the alginate shell. By twisting up cardio-fibers, we can easily prepare coiled tublar tissues. This approach would be applicable for the rapid biofabrication of large-scaled 3D tissues.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages861-863
Number of pages3
Volume2
Publication statusPublished - 2011
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

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Keywords

  • Cardiomyocyte
  • Core-shell fiber
  • Hydrogel
  • Tissue engineering

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Iwanaga, S., Onoe, H., & Takeuchi, S. (2011). Biofabrication of pseudocardiac tublar tissues with gel fibers including rat cardiomyocytes. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (Vol. 2, pp. 861-863)