Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue

Keisuke Okita, Midori Kato-Negishi, Hiroaki Onoe, Riho Gojo, Tetsuhiko Teshima, Shoji Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We propose a neural probe combined with a neuronal spheroid (neurospheroid) cultured on electrodes for deep brain stimulation. Since neurons of the spheroid extend their axons deep into the brain tissue, the neural probe can electrically stimulate deep brain area via the neurons without inserting an invasive probe. Here we first fabricated an electrode and then successfully placed a neurospheorid at the electrodes tip, named a "biohybrid neural probe". Furthermore, we tried to make the fabricated probe contact with cultured cortical cells on glass. We believe that our biohybrid neural probe has a potential to provide minimally invasive stimulation to the brain tissue.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages332-334
Number of pages3
Publication statusPublished - 2011 Dec 1
Externally publishedYes
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: 2011 Oct 22011 Oct 6

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period11/10/211/10/6

Keywords

  • Deep brain stimulation
  • Electrode
  • Neural probe
  • Neurospheroid
  • Spheroid

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Okita, K., Kato-Negishi, M., Onoe, H., Gojo, R., Teshima, T., & Takeuchi, S. (2011). Biohybrid neural probe: A neural probe having cultured neurons between an electrode and tissue. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 332-334). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).