Biological activities of phenolic oligomers (I) relationship between the degree of addition-condensation of phenolic oligomers and their antimicrobial activity

T. Uchibori, K. Kawada, S. Watanabe, K. Asakura, S. Matsumura, S. Yoshikawa

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A series of methylene-bridged phenolic oligomers was prepared and the minimal inhibitory concentrations against bacteria and fungi were determined by agar dilution method. These compounds proved to be greatly effective against gram-positive bacteria and fungi. Homogeneous all ortho methylene-bridged phenolic oligomers were synthesized and the effect of the degree of addition-condensation on antimicrobial potency was examined. Of the homogeneous oligomers, tetramers were the most active against gram-positive bacteria, and trimers showed good antimicrobial activity against fungi.

Original languageEnglish
Pages (from-to)215-218
Number of pages4
JournalJournal of Antibacterial and Antifungal Agents, Japan
Issue number5
Publication statusPublished - 1990 Jan 1
Externally publishedYes


ASJC Scopus subject areas

  • Microbiology

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