Biological activities of unique isoflavones prepared from Apios americana Medik

Haruna Kaneta, Mina Koda, Shun Saito, Masaya Imoto, Manabu Kawada, Yoko Yamazaki, Isao Momose, Kazuoshi Shindo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Four unique isoflavone aglycones (barpisoflavone A (1), 2′-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1.4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.

Original languageEnglish
Pages (from-to)774-778
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume80
Issue number4
DOIs
Publication statusPublished - 2016

Fingerprint

Glucosidases
Isoflavones
Bioactivity
Estrogens
Antioxidants
Genistein
Androgen Receptors
Estrogen Receptors

Keywords

  • Antioxidant activity
  • Apios americana Medik
  • Estrogen agonistic activity
  • Isoflavone
  • α-glucosidase inhibitory activity

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Biological activities of unique isoflavones prepared from Apios americana Medik. / Kaneta, Haruna; Koda, Mina; Saito, Shun; Imoto, Masaya; Kawada, Manabu; Yamazaki, Yoko; Momose, Isao; Shindo, Kazuoshi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 80, No. 4, 2016, p. 774-778.

Research output: Contribution to journalArticle

Kaneta, Haruna ; Koda, Mina ; Saito, Shun ; Imoto, Masaya ; Kawada, Manabu ; Yamazaki, Yoko ; Momose, Isao ; Shindo, Kazuoshi. / Biological activities of unique isoflavones prepared from Apios americana Medik. In: Bioscience, Biotechnology and Biochemistry. 2016 ; Vol. 80, No. 4. pp. 774-778.
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AU - Yamazaki, Yoko

AU - Momose, Isao

AU - Shindo, Kazuoshi

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