Biological activities of water-soluble fullerene derivatives

S. Nakamura, Tadahiko Mashino

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Three types of water-soluble fullerene derivatives were synthesized and their biological activities were investigated. C60-dimalonic acid, an anionic fullerene derivative, showed antioxidant activity such as quenching of superoxide and relief from growth inhibition of E. coli by paraquat. C 60-bis(7V,7V-dimethylpyrrolidinium iodide), a cationic fullerene derivative, has antibacterial activity and antiproliferative effect on cancer cell lines. The mechanism is suggested to be respiratory chain inhibition by reactive oxygen species produced by the cationic fullerene derivative. Proline-type fullerene derivatives showed strong inhibition activities on HIV-reverse transcriptase. The IC50 values were remarkably lower than nevirapine, a clinically used anti-HIV drug. Fullerene derivatives have a big potential for a new type of lead compound to be used as medicine.

Original languageEnglish
Article number012003
JournalJournal of Physics: Conference Series
Volume159
DOIs
Publication statusPublished - 2009

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activity (biology)
fullerenes
water
human immunodeficiency virus
lead compounds
inorganic peroxides
antioxidants
medicine
cultured cells
iodides
drugs
cancer
quenching
acids
oxygen

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Biological activities of water-soluble fullerene derivatives. / Nakamura, S.; Mashino, Tadahiko.

In: Journal of Physics: Conference Series, Vol. 159, 012003, 2009.

Research output: Contribution to journalArticle

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