Biological Effect of Carbon Beams on Cultured Human Cells

Wei Jei Ka, Hisao Ito, Naoyuki Shigematsu, Shoji Yamashita, Atushi Kubo, Tatsuaki Kanai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study was performed to determine the biological effect of carbon beams on 13 human tumor cells, in comparison with 200 KVp X-rays. Carbon beams were generated by the Riken Ring Cyclotron. The RBE (relative biological effectiveness) values were distributed from 1.46 to 2.20 for LET of 20 keV/μm, and 2.29-3.54 for 80 keV/μm. The RBEs were increased in all cell lines as the LET of carbon beams was increased from 20 to 80 keV/μm. There was no significant difference in radiosensitivity between cells from adenocarcinoma and those from squamous cell carcinoma. The relationship between the radiosensitivity of cells to X-rays and RBE was analyzed, but no significant correlation was suggested. Several survival curves of 20-40 keV/μm carbon beam irradiation showed the initial shoulders and the recovery ratios between two split doses were determined. Recovery was observed for LET of 20 keV/μm but not for that of 40 keV/μm. Furthermore, recovery ratios were 1.0-1.8, smaller than those for X-rays (1.5-2.4).

Original languageEnglish
Pages (from-to)669-673
Number of pages5
JournalNippon Acta Radiologica
Volume56
Issue number9
Publication statusPublished - 1996 Aug

Fingerprint

Linear Energy Transfer
Cultured Cells
Carbon
Relative Biological Effectiveness
Radiation Tolerance
X-Rays
Cyclotrons
Squamous Cell Carcinoma
Adenocarcinoma
Cell Line
Survival
Neoplasms

Keywords

  • Carbon beam
  • Human tumor cells
  • Linear energy transfer
  • Relative biological effectiveness

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ka, W. J., Ito, H., Shigematsu, N., Yamashita, S., Kubo, A., & Kanai, T. (1996). Biological Effect of Carbon Beams on Cultured Human Cells. Nippon Acta Radiologica, 56(9), 669-673.

Biological Effect of Carbon Beams on Cultured Human Cells. / Ka, Wei Jei; Ito, Hisao; Shigematsu, Naoyuki; Yamashita, Shoji; Kubo, Atushi; Kanai, Tatsuaki.

In: Nippon Acta Radiologica, Vol. 56, No. 9, 08.1996, p. 669-673.

Research output: Contribution to journalArticle

Ka, WJ, Ito, H, Shigematsu, N, Yamashita, S, Kubo, A & Kanai, T 1996, 'Biological Effect of Carbon Beams on Cultured Human Cells', Nippon Acta Radiologica, vol. 56, no. 9, pp. 669-673.
Ka WJ, Ito H, Shigematsu N, Yamashita S, Kubo A, Kanai T. Biological Effect of Carbon Beams on Cultured Human Cells. Nippon Acta Radiologica. 1996 Aug;56(9):669-673.
Ka, Wei Jei ; Ito, Hisao ; Shigematsu, Naoyuki ; Yamashita, Shoji ; Kubo, Atushi ; Kanai, Tatsuaki. / Biological Effect of Carbon Beams on Cultured Human Cells. In: Nippon Acta Radiologica. 1996 ; Vol. 56, No. 9. pp. 669-673.
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