Biological sciences related to headache

Toshihiko Shimizu, Norihiro Suzuki

Research output: Book/ReportBook

2 Citations (Scopus)

Abstract

Headache can occur as a result of activation of pain-sensitive cranial structures, such as the dura mater, vasculature, and the cranial and cervical muscles and ligaments, which are innervated by primary afferent neurons originating from the trigeminal and dorsal root ganglia of the upper cervical spinal nerves. Similar to general nociceptive sensation, C fibers and Aδ fibers are known to play an important role in headache perception. Findings from nerve stimulation studies indicate that C fibers transmit aching, throbbing, or burning pain that builds up slowly, whereas the Aδ fibers conduct sharper initial pain sensation. These primary afferent nerve fibers transmit nociceptive information from the pain-sensitive endings in the cranial structures through the trigeminal and first and second spinal dorsal root ganglia to the brainstem at the pontine level. The nociceptive fibers then project to the central pain-conducting pathways at the spinal trigeminal nucleus. In this chapter, we discuss the anatomy in relation to headache, including the meninges, dural sinuses, blood vessels, sensory ganglia, cranial and neck muscles, and the central pain-conducting pathways.

Original languageEnglish
PublisherUnknown Publisher
Number of pages11
Volume97
EditionC
DOIs
Publication statusPublished - 2010

Publication series

NameHandbook of Clinical Neurology
No.C
Volume97
ISSN (Print)00729752

Fingerprint

Biological Science Disciplines
Headache
Spinal Ganglia
Myelinated Nerve Fibers
Unmyelinated Nerve Fibers
Pain
Spinal Trigeminal Nucleus
Sensory Ganglia
Nociceptive Pain
Neck Muscles
Afferent Neurons
Meninges
Dura Mater
Spinal Nerves
Spinal Nerve Roots
Myalgia
Nerve Fibers
Ligaments
Brain Stem
Blood Vessels

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Shimizu, T., & Suzuki, N. (2010). Biological sciences related to headache. (C ed.) (Handbook of Clinical Neurology; Vol. 97, No. C). Unknown Publisher. https://doi.org/10.1016/S0072-9752(10)97003-6

Biological sciences related to headache. / Shimizu, Toshihiko; Suzuki, Norihiro.

C ed. Unknown Publisher, 2010. 11 p. (Handbook of Clinical Neurology; Vol. 97, No. C).

Research output: Book/ReportBook

Shimizu, T & Suzuki, N 2010, Biological sciences related to headache. Handbook of Clinical Neurology, no. C, vol. 97, vol. 97, C edn, Unknown Publisher. https://doi.org/10.1016/S0072-9752(10)97003-6
Shimizu T, Suzuki N. Biological sciences related to headache. C ed. Unknown Publisher, 2010. 11 p. (Handbook of Clinical Neurology; C). https://doi.org/10.1016/S0072-9752(10)97003-6
Shimizu, Toshihiko ; Suzuki, Norihiro. / Biological sciences related to headache. C ed. Unknown Publisher, 2010. 11 p. (Handbook of Clinical Neurology; C).
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