Biologically Active Constituents of Arnebia euchroma: Structure of Arnebinol, an Ansa-Type Mono-terpenylbenzenoid with Inhibitory Activity on Prostaglandin Biosynthesis

Xin sheng Yao, Yutaka Ebizuka, Hiroshi Noguchi, Ushio Sankawa, Fumiyuki Kiuchi, Masaaki Shibuya, Yoichi Iitaka, H. Haruo

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Three phenolic compounds were isolated from the roots of Arnebia euchroma as inhibitors of in vitro prostaglandin biosynthesis. Two known compounds were identified as shikonofurans and des-O-methyllasiodiplodin. The other new compound was named arnebinol and its structure was elucidated as a novel ansa-type monoterpenylbenzenoid derivative.

Original languageEnglish
Pages (from-to)2956-2961
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number11
DOIs
Publication statusPublished - 1991

Keywords

  • Arnebia euchroma
  • Boraginaceae
  • arnebinol
  • des-O-methyllasiodiplodin
  • inhibitor
  • prostaglandin
  • shikonofuran

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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