Biology and clinical application of neural stem cells

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Neural stem cells, which exist in various regions of the CNS throughout the mammalian lifespan, can be expanded and induced to differentiate into neurons and glia in vitro and in vivo. Because of these characteristics, there has been increasing interest in the identification and characterization of neural stem cells and neural progenitor cells both for basic developmental biology studies and for therapeutic applications to the damaged brain. Transplantation of neural stem cells or their derivatives into a host brain and the proliferation and differentiation of endogenous stem cells by pharmacological manipulations are potential treatments for many neurodegenerative diseases and brain injuries, such as Parkinson's disease, brain ischemia and spinal cord injury. Continued progress in neural stem cell research is providing a new future for brain repair.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalHormone Research
Volume60
Issue numberSUPPL. 3
DOIs
Publication statusPublished - 2003

Fingerprint

Neural Stem Cells
Brain
Stem Cells
Stem Cell Research
Developmental Biology
Brain Ischemia
Spinal Cord Injuries
Neuroglia
Neurodegenerative Diseases
Brain Injuries
Parkinson Disease
Transplantation
Pharmacology
Neurons
Therapeutics

Keywords

  • Brain repair
  • Differentiation
  • Neural stem cells
  • Regeneration
  • Specification

ASJC Scopus subject areas

  • Endocrinology

Cite this

Biology and clinical application of neural stem cells. / Shimazaki, Takuya.

In: Hormone Research, Vol. 60, No. SUPPL. 3, 2003, p. 1-9.

Research output: Contribution to journalArticle

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