Biomarkers in endometrial cancer

Possible clinical applications (review)

Kouji Banno, Iori Kisu, Megumi Yanokura, Kosuke Tsuji, Kenta Masuda, Arisa Ueki, Yusuke Kobayashi, Wataru Yamagami, Hiroyuki Nomura, Eiichirou Tominaga, Nobuyuki Susumu, Daisuke Aoki

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The number of cases of endometrial cancer has shown a tendency to increase in recent years. Endometrial cancer originates from the endometrium and is classified, based on the development mechanism, into types 1 and 2, which are responsive and non-responsive to estrogen, respectively, and have significantly different gene expression profiles. Studies of genes with abnormal expression in endometrial cancer have identified multiple oncogenes, tumor suppressors, mismatch repair genes, apoptosis-associated genes, levels of hormone receptors and DNA ploidy and aneuploidy as biomarkers of endometrial cancer. The use of these molecules and genes may facilitate accurate diagnosis and prognostic prediction and contribute to individualized treatment. Trials of drugs which target these biomarkers and searches for new biomarkers using cDNA microarrays and RT-qPCR are ongoing and it is likely that these findings can be translated to clinical use.

Original languageEnglish
Pages (from-to)1175-1180
Number of pages6
JournalOncology Letters
Volume3
Issue number6
DOIs
Publication statusPublished - 2012 Jun

Fingerprint

Endometrial Neoplasms
Biomarkers
Genes
DNA Mismatch Repair
Ploidies
Aneuploidy
Oligonucleotide Array Sequence Analysis
Oncogenes
Transcriptome
Estrogens
Hormones
Apoptosis
Pharmaceutical Preparations
Neoplasms

Keywords

  • Biomarker
  • DNA microarray
  • Endometrial cancer
  • K-ras
  • Prognosis
  • PTEN

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Biomarkers in endometrial cancer : Possible clinical applications (review). / Banno, Kouji; Kisu, Iori; Yanokura, Megumi; Tsuji, Kosuke; Masuda, Kenta; Ueki, Arisa; Kobayashi, Yusuke; Yamagami, Wataru; Nomura, Hiroyuki; Tominaga, Eiichirou; Susumu, Nobuyuki; Aoki, Daisuke.

In: Oncology Letters, Vol. 3, No. 6, 06.2012, p. 1175-1180.

Research output: Contribution to journalArticle

Banno, Kouji ; Kisu, Iori ; Yanokura, Megumi ; Tsuji, Kosuke ; Masuda, Kenta ; Ueki, Arisa ; Kobayashi, Yusuke ; Yamagami, Wataru ; Nomura, Hiroyuki ; Tominaga, Eiichirou ; Susumu, Nobuyuki ; Aoki, Daisuke. / Biomarkers in endometrial cancer : Possible clinical applications (review). In: Oncology Letters. 2012 ; Vol. 3, No. 6. pp. 1175-1180.
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