Biosynthesis of phytoecdysteroids in Ajuga hairy roots: Clerosterol as a precursor of cyasterone, isocyasterone and 29-norcyasterone

Keiko Okuzumi, Noriyuki Hara, Yoshinori Fujimoto, Junko Yamada, Atsuko Nakamura, Kyoko Takahashi, Masuo Morisaki

Research output: Contribution to journalArticle

13 Citations (Scopus)


Feeding studies of six 13C-labeled sterols, including clerosterol, to hairy roots of Ajuga reptans var. atropurpurea have established that clerosterol is a precursor of three phytoecdysteroids, cyasterone, isocyasterone and 29-norcyasterone.

Original languageEnglish
Pages (from-to)323-326
Number of pages4
JournalTetrahedron Letters
Issue number2
Publication statusPublished - 2003 Jan 6



  • 29-norcyasterone
  • Biosynthesis
  • Clerosterol
  • Codisterol
  • Cyasterone
  • Ecdysteroids
  • Isocyasterone
  • Steroids and sterols

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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